| Description | The A14 antibody is a human recombinant antibody that specifically targets the preS1 region of the Hepatitis B Virus (HBV). A14 has demonstrated a broad neutralization activity against two other HBV genotypes, namely B and C. The IC50 values for genotype B, C, and D are 80 pM, 30 pM, and 10 pM, respectively. Additionally, A14 was evaluated for its ability to neutralize six HBV genotype C viruses obtained from plasma samples of HBV-infected patients. A14 exhibited significantly higher potency compared to HBIG in neutralizing these viruses, with at least several hundred to 1000-fold greater effectiveness. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Hepatitis B Virus genotype B, C, and D |
| Isotype | IgG1 |
| Expression Species | HEK293F or CHO cell line |
| Conjugation | Unconjugated |
| Purity | >95% |
| Endotoxin | <1 EU/mg |
| Form | Liquid |
| Purification | Protein A purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics. |
| Application | ELISA; WB; Neut; ADCC |
| Application Notes | The IC50 values of A14 antibody for genotype B, C, and D are 80 pM, 30 pM, and 10 pM, respectively. |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | HBV preS1 |
| Alternative Name | Hepatitis B Virus preS1; preS1; Hepatitis B Virus; HBV |
| Research Area | Microbiology |
