Description | The antibody is a human recombinant antibody that specifically targets the preS1 region of the Hepatitis B Virus (HBV). The antibody has demonstrated a broad neutralization activity against two other HBV genotypes, namely B and C. The IC₅₀ values for genotype B, C, and D are 80 pM, 30 pM, and 10 pM, respectively. Additionally, the clone was evaluated for its ability to neutralize six HBV genotype C viruses obtained from plasma samples of HBV-infected patients. The antibody exhibited significantly higher potency compared to HBIG in neutralizing these viruses, with at least several hundred to 1000-fold greater effectiveness. |
Clonality | Monoclonal |
Host Species | Human |
Target Species | Hepatitis B Virus genotype B, C, and D |
Isotype | IgG1 |
Expression Species | HEK293F or CHO cell line |
Conjugation | Unconjugated |
Purity | >95% |
Endotoxin | <1 EU/mg |
Form | Liquid |
Purification | Protein A purified |
Sterility | 0.2 μM filtered |
Formulation | PBS, pH 7.4 |
Preservation | No preservatives |
Stabilizer | No stabilizers |
Storage | Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics. |
Application | ELISA; WB; Neut; ADCC |
Application Notes | The IC₅₀ values of the antibody for genotype B, C, and D are 80 pM, 30 pM, and 10 pM, respectively. |
ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
WB | Western Blot Protocol |
FC | Flow Cytometry Protocol |
Target | HBV preS1 |
Alternative Name | Hepatitis B Virus preS1; preS1; Hepatitis B Virus; HBV |
Research Area | Microbiology |