| Description | This product is a human antibody AR3X that identifies the HCV envelope glycoprotein E2. AR3X also identified E2 envelopes from genotypes 2, 3, 4, 5, and 6. AR3X is distinctive for its unusually long CDRH2 insertion, which forms extensive connections with E2. However, this does not alter AR3X's preconfigured mode of interaction with E2, which is based on its straight CDRH3 containing a disulfide motif. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Hepatitis C Virus (HCV) |
| Cross Reactivity | HCV2, HCV3, HCV4, HCV5, HCV6 |
| IC50 | The AR3X neutralization IC₅₀ for strain 1b21 is approximately 17 times lower than the IC₅₀ of HEPC3 (1.2 vs. 20.5 µg/mL). Conversely, the AR3X neutralization IC₅₀ for strain 1a142 is approximately 9 times higher than the IC₅₀ of HEPC3 (16.2 vs. 1.9 µg/mL). |
| Isotype | Human IgG |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein A purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | ELISA; Neut |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | HCV E2 |
| Alternative Name | HCV envelope glycoprotein E2; HCV; hepatitis C virus; envelope; E2 |
| Research Area | Microbiology |
