| Description | The product is capable of binding of IL-1α and IL-1β. The mAb is a human IgG1, kappa antibody (clone 2-108-538X/ABT1-95-15). It can neutralize both IL-1α and IL-1β. The neutralization of the dAb was determined in the MRC5 bioassay, yielding a value of 8 nM for IL-1α and 0.042 nM for IL-1β. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Human |
| IC50 | 0.9 nM (IL1A), 0.003 nM (IL1B) |
| EC50 | 0.6638 nM (IL1A) |
| ND50 | 45 pM |
| Affinity | KD = 0.4 nM |
| Isotype | Human IgG1 |
| Expression Species | HEK293F or CHO |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein A affinity purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | ELISA; Neut |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
