| Description | This product is a human neutralizing antibody specific for MERS-COV S glycoprotein. It also has cross-reactivity against SARS-CoV-2. This antibody targets the stem helix (SH) region of CoV spike protein and potently neutralizes SARS-CoV-2 original strain, delta, and omicron VoC and MERS-CoV. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | MERS-CoV, SARS-CoV, SARS-CoV-2 |
| Epitope | Stem helix (SH) region or residues 743-749 of SARS-CoV-2 S loop. |
| Neutralization Mechanism | It targets the stem helix (SH) region of CoV spike protein. |
| Affinity | KD = 3.28 nM (SARS-CoV-2 S) KD = 0.42 nM (SH-FC fusion protein) |
| Isotype | IgG |
| Expression Species | HEK293F or CHO cell |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Form | Liquid |
| Purification | Protein A purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics. |
| Application | ELISA; SPR; Neut |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | MERS-CoV S |
| Alternative Name | Middle East respiratory syndrome coronavirus spike glycoprotein |
| Research Area | Infectious Disease |
| Related Disease | Respiratory tract infections, Atypical pneumonia |
