| Description | This product is a human monoclonal antibody specifically designed to target the G glycoprotein of Respiratory Syncytial Virus (RSV). It is a non-neutralizing anti-RSV G protein antibody that effectively inhibits the binding of RSV G protein to CX3CR1 and prevents RSV G protein-induced chemotaxis. In a murine model of RSV infection, treatment with this monoclonal antibody not only decreased pulmonary inflammation and the production of inflammatory cytokines but also enhanced virus clearance. Notably, its F(ab')2 fragment is responsible for reducing leukocyte trafficking and IFN-γ production, without affecting viral replication. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Human Respiratory Syncytical Virus |
| Isotype | IgG1 kappa |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and/or SEC-HPLC |
| Endotoxin | <1 EU/mg, determined by LAL method |
| Purification | Protein A affinity purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4⁰C within a week. For longer storage, aliquot and store at -20⁰C. |
| Application | ELISA; Inhib |
| Application Notes | The antibody is recommended for detection of Respiratory Syncytial Virus G glycoprotein by ELISA and Inhibition assays. |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | Respiratory Syncytial Virus G glycoprotein |
| Alternative Name | Respiratory Syncytial Virus G; Respiratory Syncytial Virus G protein |
| Research Area | Infectious Disease |
