| Description | The mAb is a mouse IgG2a antibody which binds SBV GP with high affinity. The antibody provides protection against lethal SBV infection in IFNAR-/- mice. Using biolayer interferometry, the affinity of the head-stalk fragment of SBV Gc (aa 465-874) for the full-length recombinant antibody was determined. The recombinant SBV head-stalk construct showed binding to these antibodies with dissociation constants of KD= 36 ± 4 nM. |
| Clonality | Monoclonal |
| Host Species | Mouse |
| Target Species | Schmallenberg virus (SBV) |
| ND50 | 1.8 ± 0.1 µM |
| Affinity | Recombinant SBV head-stalk construct: KD = 36 nM |
| Isotype | Mouse IgG2a |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein G purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | ELISA; Neut |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | SBV GP |
| Alternative Name | Schmallenberg Virus Glycoprotein; Schmallenberg Virus; Glycoprotein; SBV; GP; Orthobunyaviruses; OBVs; Schmallenberg orthobunyavirus |
| Research Area | Microbiology |
