| Description | This is a human antibody that specifically targets human SIRPA. The clone is effective against both human and cynomolgus monkey SIRPα. It strongly inhibits the interaction between SIRPα and CD47, with an IC₅₀ of approximately 0.3 nM. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Human, Monkey |
| Cross Reactivity | Human SIRPα v1 and v2 alleles and cynomolgus SIRPα |
| IC50 | 0.3 nM |
| EC50 | 0.3 nM |
| Affinity | KD = 1 pM (human) KD = 100 pM (cynomolgus) |
| Isotype | Human IgG |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein A purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | ELISA; Block |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | SIRPA |
| Alternative Name | BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1; tyrosine-protein phosphatase non-receptor type substrate 1; CD172 antigen-like family member A; brain-immunoglobulin-like molecule with tyrosine-based activation motifs; inhibitory receptor SHPS-1; macrophage fusion receptor; myd-1 antigen; tyrosine phosphatase SHP substrate 1 |
| Gene ID | 140885 |
| UniProt | P78324 |
| Research Area | Neuroscience |
