| Description | The hMEM102 is a human antibody that specifically binds to human CD48. It also cross-reacts with cynomolgus monkey CD48. It has been utilized in in vivo activity or ADCC assay. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Human, Cynomolgus |
| Affinity | KD = 5 nM (U-266), KD = 31.1 nM (CHO-DG44 cynomolgus monkey CD48). |
| Isotype | Human IgG1 |
| Expression Species | HEK293F or CHO |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein A affinity purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | ADCC; In vivo assay |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | CD48 |
| Alternative Name | CD48 Molecule; Signaling Lymphocytic Activation Molecule 2; CD48 Antigen (B-Cell Membrane Protein); B-Lymphocyte Activation Marker BLAST-1; Leukocyte Antigen MEM-102; BCM1 Surface Antigen; SLAM Family Member 2; CD48 Antigen; BLAST1 |
| Gene ID | 962 |
| UniProt | P09326 |
| Related pathway | NF-κB signaling pathway |
| Research Area | Neuroscience; Signal Pathway |
| Related Disease | Multiple myeloma, and other B cell malignancies, including Hodgkin's disease, non-Hodgkin's lymphoma, Follicular lymphoma, Chronic lymphocytic leukemia (CLL), Mantle cell lymphoma, Waldenstrom's macroglobulinemia, Primary/Systemic amyloidosis patient tumor cells, MGUS, and Amyloidosis |
