| Description | This antibody can block mesothelin binding to macrophages and prevent tumor-induced phenotype polarization of CD206low macrophages towards TAMs. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Human |
| Immunogen | A yeast-secreted recombinant CRD4-MR protein (rCRD4-MR) |
| Epitope | Mannose receptor domain 4 (CDR4-MR) |
| Neutralization Mechanism | Block mesothelin binding to macrophages and prevent tumor-induced phenotype polarization of CD206low macrophages. |
| Isotype | Human IgG1 |
| Expression Species | HEK293F or CHO cell line |
| Conjugation | Unconjugated |
| Purity | >95% |
| Endotoxin | <1 EU/mg |
| Form | Liquid |
| Purification | Protein A purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservative |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | ELISA; WB; FC; Block |
| Application Notes | ELISA: 5-10 mg/mL |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
