| Description | The 2B12-H2L1 antibody is a recombinant human antibody that recognizes Human KIR3DL2. The anti-KIR3DL2 mAb 2B12 has the favorable property of not binding to the closely related (homologous) KIR3DL1, nor causing internalization of KIR3DL2. KIR3DL2 internalization strongly hinders ADCC-based approaches. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Human |
| Isotype | IgG1 |
| Expression Species | HEK293F or CHO cell line |
| Conjugation | Unconjugated |
| Purity | >95% |
| Endotoxin | <1 EU/mg |
| Form | Liquid |
| Purification | Protein A purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics. |
| Application | ELISA; ADCC |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | KIR3DL2 |
| Alternative Name | Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 2; Killer Cell Immunoglobulin-Like Receptor, Three Domains, Long Cytoplasmic Tail, 2; P70 Natural Killer Cell Receptor Clone CL-5; Natural Killer-Associated Transcript 4; CD158 Antigen-Like Family Member K; MHC Class I NK Cell Receptor; P70 NK Receptor CL-5; CD158K; NKAT-4; NKAT4; Killer Cell Immunoglobulin-Like Receptor 3DL2 |
| Gene ID | 3812 |
| UniProt | P43630 |
| Research Area | Immunology |
