| Description | This product is a human antibody that recognizes neisseria meningitidis fHbp variant 3. This antibody binds to fHbp variant 3 of Neisseria meningitidis. It is able to elicit complement-mediated bactericidal activity in rabbits, but not human, against fHbp-displaying meningococci from any of 3 different variant groups. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Neisseria meningitidis |
| Affinity | KD = 0.265 nM (fHbp v1) KD = 0.036 nM (fHbp v2) KD = 2.7 nM (fHbp v3) |
| Isotype | Human IgG |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein A purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | ELISA; FC; SPR |
| Application Notes | SPR: 10 ug/mL |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | N. meningitidis fHbp variant 3 |
| Alternative Name | Neisseria meningitidis fHbp variant 3; Neisseria meningitidis; fHbp variant 3; Neisseria meningitidis factor H binding protein; factor H binding protein; fHbp v3 |
| Research Area | Microbiology |
