| Description | This product is a human antibody that recognizes the Plasmodium falciparum circumsporozoite protein NANP repeat, (N/D)PNANPN(V/A). mAb 2541 bound NANP and NVDP with high affinity and showed cross-reactivity with NPDP. NPDP and NVDP here represent aa 101-116 (NPDPNANPNVDPNANP) and aa 109-128 (NVDPNANPNVDPNANPNVDP), respectively. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Plasmodium falciparum |
| Immunogen | Live sporozoites under chemoprophylaxis (PfSPZ-CVac) |
| Epitope | NANPNANPNANP, named NANP |
| Affinity | KD = 197 nM (NANPNANPNANP) KD = 203 nM (NVDPNANPNVDP) |
| Isotype | Human IgG1 |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein A purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | ELISA; SPR |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | PfCSP NANP repeat |
| Alternative Name | NANA; Circumsporozoite protein NANA; PfCSP; CSP; Circumsporozoite protein |
| Research Area | Infectious Disease |
