| Description | This product is a humanized IgG4 antibody that recognizes human tryptase. This anti-tryptase antibody effectively blocks tryptase activity in a humanized mouse model, reduces IgE-mediated systemic allergic reactions, and inhibits airway tryptase in ascaris-sensitized cynomolgus monkeys with promising results. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Human, Monkey |
| IC50 | 0.36 nM |
| Affinity | KD = 0.27 nM |
| Isotype | Human IgG4 |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein A purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | ELISA; Inhib; FuncS |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | Tryptase |
| Alternative Name | Tryptase |
| Research Area | Cell Biology |
