| Description | This product is a murine IgG2a monoclonal antibody. It has inverse agonist activity that inhibits TSHR constitutive activity. CS-17 binds to TSHR residue tyrosine 195 (Y195) with an affinity of 87 pM. |
| Clonality | Monoclonal |
| Host Species | Mouse |
| Target Species | Human |
| Immunogen | Recombinant human TSHR A-subunit (amino acids 22-289). |
| Epitope | AA 22-289 |
| Affinity | KD = 87 pM |
| Isotype | Mouse IgG2a |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein G purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | ELISA; FC; Agonist |
| Application Notes | FC: 1 µg of this antibody detected the TSH Receptor in one million TSH-R transfected HEK293 cells. |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
