Campylobacter Specific Neutra™ Antibody Products
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Are you currently facing challenges in accurately and rapidly detecting Campylobacter strains, differentiating closely related species, or developing highly sensitive diagnostic assays for food safety and clinical surveillance? Our Campylobacter Specific Neutra™ Antibody Products help you accelerate foodborne pathogen research, obtain high-quality reagents for serodiagnostics, and develop highly specific detection platforms through advanced proprietary antibody engineering techniques.
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Introduction of Campylobacter
Campylobacter is a genus of Gram-negative, helical or curved rod-shaped bacteria, a leading bacterial cause of foodborne gastroenteritis worldwide, with C. jejuni and C. coli being the most common pathogens. These microaerophilic bacteria are highly motile and thrive optimally at 42℃.
Structure and Virulence Factors: Pathogenicity relies on key surface-exposed virulence factors.
- Flagella Components: FlaA and FlaB subunits are crucial for motility, colonization, and invasion, featuring essential O-linked glycosylation modifications.
- Lipooligosaccharide (LOS): This outer membrane component mediates immune evasion and adherence. Molecular mimicry between specific LOS structures and human neuronal gangliosides is implicated in autoimmune sequelae like GBS.
- Capsular Polysaccharide (CPS): Forms a protective layer, conferring complement resistance and aiding epithelial cell invasion through structures like O-methyl phosphoramidate (MeOPN).
Campylobacter infection causes inflammatory diarrheal illness (campylobacteriosis). The potential for severe neurological complications, triggered by cross-reactivity with neural structures, emphasizes the need for precise research tools.
Fig.1 Campylobacter jejuni induced immunopathological responses within the intestinal tract.1
Antibodies Against Campylobacter
Antibodies targeting Campylobacter offer rapid, culture-independent detection crucial for high-volume testing in clinical and food safety settings, moving beyond slow culture-based methods.
Key Applications of Campylobacter Specific Antibodies:
| Application Area | Antibody Function and Significance |
| Direct Antigen Detection | Used in Sandwich ELISA or Lateral Flow Devices to capture and detect Campylobacter antigens (e.g., surface proteins, LOS) directly from food or clinical samples for fast, low-infrastructure testing. |
| Serodiagnosis | Used in ELISA to quantify host antibodies （IgG, IgM, IgA） against Campylobacter antigens, confirming active infection and diagnosing extra-intestinal complications like GBS. |
| Strain Typing and Differentiation | Targets specific O-polysaccharide or H-protein serogroup determinants, differentiating clinically relevant serotypes for outbreak investigations. |
| Immunohistochemistry/Immunofluorescence | Localizes bacteria or antigens in tissue or cell culture models, providing insights into host-pathogen interactions and invasion. |
The quality of diagnostic tests is heavily reliant on the antigen preparation used, underscoring the value of highly specific, characterized antibodies, such as those engineered by Creative Biolabs, that recognize conserved and clinically relevant epitopes.
Why Choose Us?
We provide highly reliable, high-performance Campylobacter antibody products with unparalleled specificity and affinity.
- Proprietary Neutra™ Engineering: Superior binding kinetics and robust performance minimize non-specific binding in complex matrices.
- Focused Virulence Targeting: Prioritizing antibodies against functionally relevant, conserved proteins (HtrA, FlaA/B) and surface structures (LOS, CPS).
- Guaranteed Consistency: Rigorous QC ensures consistent lot-to-lot quality, critical for manufacturing diagnostic kits and longitudinal studies.
FAQs
Q: Can these antibodies differentiate between C. jejuni and C. coli?
A: Yes, many products use species-specific epitopes for high-accuracy differentiation vital for epidemiological and source-tracking studies.
Q: What is the optimal use-case for these antibodies compared to molecular methods like PCR?
A: Antibody assays detect the actual protein or surface antigen, critical for assessing actively expressed pathogens or for serological tests detecting host immune response. Immunoassays are generally simpler and more cost-effective for high-throughput screening and point-of-care rapid diagnostics.
Q: How sensitive are these reagents for detecting low-level contamination in complex food matrices?
A: Our antibodies are engineered for high affinity, which enhances sensitivity. Their specificity minimizes background noise from complex food environments, allowing reliable detection of lower Colony Forming Unit (CFU) equivalents.
Q: Are there considerations regarding cross-reactivity with host antigens (GBS)?
A: Non-specific binding is meticulously managed. For research into molecular mimicry related to GBS, we offer specialized reagents designed to investigate this cross-reactivity precisely.
Q: What is the benefit of utilizing a proprietary engineering approach?
A: Our proprietary method ensures enhanced control, resulting in highly refined antibodies with defined binding characteristics, optimal stability, and verified performance, reducing the need for extensive in-house optimization.
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REFERENCE
- Mousavi, Soraya et al. "Novel Clinical Campylobacter jejuni Infection Models Based on Sensitization of Mice to Lipooligosaccharide, a Major Bacterial Factor Triggering Innate Immune Responses in Human Campylobacteriosis." Microorganisms vol. 8,4 482. 28 Mar. 2020, Distributed under Open Access license CC BY 4.0, without modification. https://doi.org/10.3390/microorganisms8040482
