CRTAM Specific Neutra™ Antibody Products

CRTAM (Cytotoxic and Regulatory T Cell Molecule), a Class-I-restricted T cell-associated molecule, is a protein molecule located on the surface of the cell that plays a critical role in the immune response. It is highly expressed in activated CD4⁺ and CD8⁺ T cells, natural killer T cells (NKT cells), and a subset of natural killer cells (NK cells).

Its Gene ID: 56253, UniProtKB ID: Q8TDN4, and OMIM ID: 608667.

CRTAM/Necl-2 (CADM1) Pathway

• CRTAM and Necl-2(CADM1) interaction: CRTAM is involved in multiple immune pathways, particularly those related to T cell activation and migration. It interacts with its ligand, Necl-2(CADM1, cell adhesion molecule 1), which is expressed on antigen-presenting cells and epithelial cells. The interaction between CRTAM and Necl-2 affects the immune response's quality and potency.
• CRTAM and T cell regulation: The engagement of CRTAM by its ligand Necl-2 stimulates the production and release of Th1-type cytokines such as IFN-γ and TNF-α, enhancing the cytotoxic activity of T cells and guiding adaptive immune responses.
• CRTAM in inflammatory diseases: In various types of inflammatory diseases, the CRTAM/Necl-2 pathway is known to be upregulated, contributing to persistent inflammation and tissue damage if not well controlled.
• CRTAM in cancer immunotherapy: The CRTAM/NecL-2 pathway has substantial potential for cancer immunotherapy. Clinicians and researchers can better target cancer cells by stimulating the immune system by altering CRTAM activity using agonists or antibodies.
• CRTAM in viral infections: CRTAM has been identified to have a potential role in the immune response against several viral infections, enhancing the ability of cytotoxic T cells to recognize and destroy virus-infected cells.

CRTAM Antibody Therapeutic Potential

Numerous inflammatory disorders and autoimmune diseases have been connected to CRTAM in research. Studies have shown that the level of CRTAM expression is higher in the synovial tissue of individuals with rheumatoid arthritis, suggesting that it may have a significant role in the development and progression of the disease. Moreover, in relation to viral infections and malignancies, CRTAM has been associated with the regulation of immune responses.

Antibodies targeting CRTAM have shown promise as potential therapeutic agents in autoimmune diseases and cancer. By blocking the interaction between CRTAM and CADM1, these antibodies can modulate T-cell responses and inhibit inflammation. In cancer immunotherapy, CRTAM antibodies may enhance anti-tumor immune responses by promoting T cell infiltration into the tumor microenvironment and enhancing T cell-mediated cytotoxicity against tumor cells.

Fig.1 Overview of CRTAM pathway-involved immune effector functions.¹

The CRTAM pathway is critical for an effective immune response and has potential applications in immunotherapy for cancer and other diseases. Creative Biolabs provides a series of CRTAM antibody products for research use.

REFERENCE

1. Hermans, Doryssa, Lisa van Beers, and Bieke Broux. "Nectin family ligands trigger immune effector functions in health and autoimmunity." Biology 12.3 (2023): 452. Distributed under Open Access license CC BY 4.0. The image was modified by revising the title.