Ebolaviruses are zoonotic pathogens that cause severe hemorrhagic fever in humans, known as Ebola disease. There are four species of Ebolaviruses that are known to cause disease in humans. Of these, Ebola virus (EBOV; species Zaire ebolavirus), the cause of Ebola virus disease (EVD), is the most lethal, with case fatality rates of 70-90% if left untreated. EBOV is responsible for the majority of recorded Ebola disease outbreaks. This includes the two largest Ebola disease outbreaks in history, the 2014-2016 West Africa outbreak and the 2018 outbreak in eastern Democratic Republic of the Congo, where over 32,000 people were infected, and more than 13,600 deaths were reported.