Epithelial Cell Specific Neutra™ Antibody Products

Are lengthy therapeutic development timelines or challenges in targeting epithelial-specific markers hindering your research? Creative Biolabs' epithelial cell specific Neutra™ antibody products utilize advanced recombinant protein engineering to streamline drug discovery and enable precise modulation of epithelial-related pathologies.

Introduction to Epithelial Cell

Epithelial cells form the structural foundation of epithelial tissues, lining organs and cavities to regulate barrier integrity, selective transport, and secretion. These polarized cells are interconnected via specialized junctions, including tight junctions and adherens complexes, which maintain tissue architecture and mediate mechanical resilience. Their dynamic roles in homeostasis, wound healing, and disease progression make them critical targets for biomedical research.

• Structure

Epithelial cells exhibit apical-basal polarity, governed by cytoskeletal organization and junctional complexes. Adherens junctions, anchored by E-cadherin, are essential for cell-cell adhesion and Mechan transduction. Cryo-EM studies reveal that E-cadherin extracellular domains form calcium-dependent dimers, while intracellular domains interact with β-catenin to link the actin cytoskeleton. This structural framework enables epithelial sheets to withstand mechanical stress and coordinate collective behaviors during morphogenesis.

• Related Signaling Pathways

Key pathways include the RhoA/ROCK axis, which regulates actomyosin contractility to protect epithelial integrity under tensile stress. The Wnt/β-catenin pathway also modulates epithelial proliferation and differentiation, while TGF-β signaling drives epithelial-mesenchymal transition (EMT), a hallmark of carcinoma progression.

• Pathologies

Epithelial dysfunction underpins diverse diseases. Carcinomas, constituting 80%–90% of human cancers, often arise from EMT-driven metastasis. Inflammatory disorders like Crohn's disease involve disrupted epithelial barrier function, while chronic infections (e.g., Helicobacter pylori) exploit epithelial receptors for colonization.

Fig.1 Signal transduction pathways of epithelial cells involved in the recognition of pathogenic bacteria.¹

Applications of Epithelial Cell-Neutralizing Antibodies

• Therapeutic Development for Carcinomas

Neutralizing antibodies targeting EMT drivers (e.g., Twist or Snail transcription factors) restore epithelial phenotypes in metastatic cells. Anti-EpCAM antibodies conjugated to cytotoxic payloads selectively eradicate circulating tumor cells, reducing metastatic burden.

• Management of Inflammatory Disorders

Antibodies against epithelial tight junction proteins (e.g., claudins) mitigate intestinal permeability in colitis models. Neutralizing IL-13 receptor antibodies, which attenuate goblet cell hyperplasia, are being evaluated for eosinophilic esophagitis.

• Targeted Drug Delivery Systems

Antibody-drug conjugates (ADCs) leveraging epithelial-specific receptors (e.g., folate receptor α) enhance tumor-selective cytotoxicity. Bispecific antibodies engaging epithelial receptors and immune checkpoints (e.g., PD-1) potentiate antitumor T-cell activity.

Our Anti-Epithelial Cell Antibodies

Anti-epithelial antibodies enable precise interrogation of pathogenesis. For instance, anti-E-cadherin antibodies quantify junctional integrity in cancer biopsies, correlating with metastatic potential. Neutralizing antibodies against epithelial adhesion molecules (e.g., EpCAM) block tumor cell dissemination in preclinical models. Creative Biolabs' portfolio includes high-affinity antibodies validated for applications such as:

- Immunohistochemistry: Spatial mapping of epithelial biomarkers in tissue sections.

- Flow Cytometry: Isolation and characterization of epithelial progenitor populations.

- Functional Blockade: Inhibiting receptor-ligand interactions in disease models.

Creative Biolabs' epithelial cell specific Neutra™ antibody products empower researchers to dissect epithelial biology with unparalleled precision. Our rigorously validated antibodies accelerate therapeutic discovery across oncology, immunology, and regenerative medicine.

Contact our team today to discuss your project requirements and explore tailored solutions for your research challenges.

REFERENCE

1. Medina-Estrada, Ivan, et al. "Immunomodulatory Effects of 17β‐Estradiol on Epithelial Cells During Bacterial Infections." Journal of Immunology Research 2018.1 (2018): 6098961. Distributed under Open Access license CC BY 4.0, without modification. https://doi.org/10.1155/2018/6098961