Fas cell surface death receptor
Fas cell surface death receptor is a member of the TNF-receptor superfamily. It contains a death domain. It has been shown to play an essential role in the physiological regulation of programmed cell death and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of FAS with its ligand allows the formation of a death-inducing signaling complex that includes FADD (Fas-associated death domain protein), caspase 8, and caspase 10.