FSHB Specific Neutra™ Antibody Products

Are you struggling with prolonged timelines in infertility therapy development or inconsistent results in FSH-mediated signaling research? Creative Biolabs' FSHB specific Neutra™ antibody products leverage advanced hybridoma technology and epitope-specific validation to deliver high-affinity antibodies, enabling precise modulation of FSH activity and accelerating therapeutic discovery.

Introduction to FSHB

Follicle-stimulating hormone subunit beta (FSHB) is a critical component of follicle-stimulating hormone (FSH), a heterodimeric glycoprotein essential for regulating reproductive processes. As the beta subunit, FSHB confers biological specificity to FSH by binding to its receptor (FSHR) on ovarian granulosa cells and testicular Sertoli cells, activating downstream pathways that govern gametogenesis and steroidogenesis.

• Structure

FSHB comprises 129 amino acids, including a conserved cysteine-knot motif that stabilizes the protein's tertiary structure through disulfide bonds. It non-covalently associates with the alpha subunit (CGA) to form the functional FSH heterodimer. Post-translational glycosylation at Asn-7 and Asn-24 modulates hormone stability, half-life, and receptor-binding efficacy, making these sites critical for therapeutic targeting.

• Related Signaling Pathways

FSHB-mediated FSH signaling primarily activates the cAMP/PKA pathway, driving aromatase expression and estradiol synthesis in females. In males, it stimulates Sertoli cell proliferation via PI3K/AKT, supporting spermatogenesis. Dysregulation of these pathways is linked to pathologies such as hypogonadism and polycystic ovary syndrome (PCOS).

Fig.1 Mechanism of action of FSH in the Sertoli cell.¹

• Associated Pathologies

FSHB overexpression or mutations are implicated in reproductive disorders, including primary ovarian insufficiency, male infertility, and ovarian hyperstimulation syndrome (OHSS). Elevated FSH levels correlate with menopause onset, while FSHB polymorphisms may influence fertility treatment outcomes.

Applications of Anti-FSHB Neutralizing Antibodies

• Therapeutic Intervention in Infertility

FSHB neutralizing antibodies can suppress aberrant FSH signaling in ovarian hyperstimulation syndromes, reducing the risk of iatrogenic OHSS during assisted reproductive therapies. Preclinical models demonstrate their efficacy in restoring hormonal balance without compromising ovarian reserve, offering a safer, more controlled stimulation protocol.

• Management of Hormone-Dependent Cancers

By inhibiting FSH-driven proliferation in FSHR-positive cancers (e.g., ovarian granulosa cell tumors), these antibodies offer a targeted approach to reduce tumor growth and metastasis, serving as a promising adjuvant therapy.

• Development of Diagnostic Assays

High-specificity Anti-FSHB antibodies enable ultrasensitive detection of FSH isoforms in serum, aiding in the diagnosis of pituitary disorders and monitoring of fertility treatments, providing clinicians with a precise diagnostic tool.

• Preclinical Research Tools

Researchers utilize these antibodies to map FSHB-receptor binding domains, facilitating the design of small-molecule inhibitors or peptide mimetics for next-generation therapeutics, accelerating drug discovery in reproductive endocrinology.

Anti-FSHB Antibodies

Neutralizing antibodies against FSHB disrupt FSH-FSHR interactions, offering therapeutic potential for conditions driven by excessive FSH activity. Creative Biolabs' anti-FSHB antibodies are rigorously validated for specificity and affinity, with applications ranging from quantitative ELISA to functional blockade assays. Engineered to recognize conformational epitopes near the receptor-binding interface, these antibodies exhibit minimal cross-reactivity with related gonadotropins, ensuring reliable data in preclinical studies.

Creative Biolabs' FSHB specific Neutra™ antibody products combine cutting-edge bioengineering with rigorous validation to empower your research and therapeutic development. Contact our team today to discuss custom solutions tailored to your project needs.

REFERENCE

1. Santi, Daniele, et al. "Follicle-stimulating hormone (FSH) action on spermatogenesis: a focus on physiological and therapeutic roles." Journal of Clinical Medicine 9.4 (2020): 1014. Distributed under Open Access license CC BY 4.0, without modification. https://doi.org/10.3390/jcm9041014