N-Acetylgalactosamine (GalNAc), is an amino sugar derivative of galactose. N-Acetylgalactosamine is necessary for intercellular communication, and is concentrated in sensory nerve structures of both humans and animals. N-Acetylglucosamine (GlcNAc) an amide derivative of the monosaccharide glucose. It is a secondary amide between glucosamine and acetic acid. It is significant in several biological systems. There remains a need for improved diagnostic and therapeutic agents that specifically bind to one or more saccharides (e.g., N-acetylglucosamine and N-acetyl-galactosamine), which may be useful, inter alia, for the treatment of cancer, inflammatory, and/or autoimmune diseases.