HIV1 is equipped with the envelope gp160 glycoprotein for interaction with LCs (Langerhans cells) and DCs (dendritic cells), the members of the innate immune system, which confront the virus at the portal of virus entry in the human body. These cells are equipped with receptors by which they bind and endocytose the virus. The gp120 glycoprotein is used for binding to CD4 receptor and CCR5 co-receptor of Th2 (T helper 2) cells, and is able to induce FcepsilonRI(+) hematopoietic cells to produce IL4, which inactivates the host adaptive immune response.