HIV gp160 Specific Neutra™ Antibody Products
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Are you currently facing challenges in developing effective HIV therapies, designing potent vaccine candidates, or creating reliable diagnostic assays? Our HIV gp160 Specific Antibody Products from Creative Biolabs help you accelerate viral research, obtain high-quality reagents, and develop highly specific tools for your projects through advanced protein engineering techniques and high-affinity antibody development. With our solutions, you can streamline your research workflows and overcome critical obstacles in HIV/AIDS studies.
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Introduction of HIV gp160
HIV envelope glycoprotein gp160 is a precursor protein encoded by the env gene. Synthesized and oligomerized into a trimeric complex, it is cleaved into its two subunits: the surface glycoprotein gp120 and the transmembrane glycoprotein gp41. This trimeric spike, found on the mature HIV virion, is essential for viral attachment and entry. The gp120 subunit binds to the host cell receptor CD4 and a co-receptor, triggering a conformational change that exposes gp41. The gp41 then mediates fusion of the viral envelope with the host cell membrane, allowing the viral core to enter. Due to its key role in viral entry, gp160 is a primary target for neutralizing antibodies and a major focus for HIV vaccine development.
Fig.1 HIV-1 gp160 protein structure and post-translational modifications.1
Our Anti-HIV gp160 Antibody Products
Antibodies targeting the HIV gp160 envelope glycoprotein are invaluable tools in virology and immunology. Their applications are broad, ranging from fundamental research to clinical diagnostics. In research, anti-gp160 antibodies are used to characterize the structure and function of the viral envelope spike, investigate its interaction with host receptors, and study the mechanisms of viral entry and immune evasion. Researchers employ them in techniques like Western blotting to detect the gp160 precursor and its cleaved subunits, and in immunofluorescence to visualize the protein's localization on infected cells. In diagnostics, antibodies specific to gp160 are utilized in high-sensitivity assays like ELISAs for the detection of HIV infection or for monitoring the patient's immune response to the virus. Furthermore, a major focus of therapeutic development is on broadly neutralizing antibodies (bNAbs) that target conserved epitopes on gp160, offering a promising avenue for passive immunization and a functional cure for HIV. Our gp160 specific antibodies are designed to support all these applications, providing a reliable foundation for your critical work.
Why Choose Us?
Creative Biolabs is a trusted partner in the development of high-quality biological reagents for the most demanding research. Our commitment to excellence is reflected in every product we deliver. When you choose us, you are leveraging decades of scientific expertise and a rigorous quality control process to ensure the highest standards for your research.
- Exceptional Specificity: Our antibodies undergo extensive validation to ensure minimal cross-reactivity, providing clean and specific signals in your assays. Published data has demonstrated high specificity in various applications.
- Lot-to-Lot Consistency: We guarantee superior reproducibility, ensuring that your long-term projects are not compromised by variability in reagent performance.
- Comprehensive Application Support: Our products are validated for a wide range of applications, including Western blot, ELISA, and more, offering a versatile tool for your laboratory.
FAQs
Q: How can antibodies against this target protein assist in my research into viral entry and host-pathogen interactions?
A: High-quality antibodies are a cornerstone of this type of research. They can be used to visualize the protein on the cell surface, quantify its expression levels, or block its interaction with host receptors, thereby providing key insights into the mechanism of viral entry and the host immune response.
Q: Are these antibodies suitable for use with different HIV isolates or subtypes?
A: The HIV envelope glycoprotein is highly variable. Our antibodies are designed to recognize and bind to conserved epitopes on the protein. We recommend inquiring about specific product details to ensure the antibody is validated for your particular strain or subtype of interest.
Q: How can these antibodies be used for vaccine development or therapeutic screening?
A: In vaccine research, these antibodies can be used to characterize the antigenicity of vaccine candidates. For therapeutic screening, they can serve as a benchmark to compare the binding affinity and specificity of newly developed molecules, such as small-molecule inhibitors or novel antibody therapeutics.
Q: Do these antibodies come with validation data for their performance in various applications?
A: Yes, each product is accompanied by a detailed datasheet with a range of validation data, including Western blot, ELISA, and other relevant application results, to ensure you have the necessary information to get started with confidence.
Q: Can I use these antibodies for detecting viral load in clinical samples?
A: While our products are primarily for research use, they are developed with the precision and specificity needed for diagnostic applications. We encourage you to contact us directly to discuss your specific project needs and regulatory requirements.
Creative Biolabs' team of expert scientists is ready to assist you in selecting the right product or developing a custom solution tailored to your specific research needs. We are committed to supporting your project from concept to completion, ensuring you achieve accurate and reliable results.
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REFERENCE
- Elalouf, Amir, Hanan Maoz, and Amit Yaniv Rosenfeld. "Comprehensive Insights into the molecular basis of HIV glycoproteins." Applied Sciences 14.18 (2024): 8271, Distributed under Open Access license CC BY 4.0, without modification. https://doi.org/10.3390/app14188271
