Human papillomavirus type 16 protein E6

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Human papillomavirus is a DNA virus from the papillomavirus family, of which over 150 types are known. HPV16 E6 protein plays a major role in the induction and maintenance of cellular transformation and acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT).

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Recombinant Anti-HPV16 E6 Antibody (V3S-0522-YC3769) (CAT#: V3S-0522-YC3769)

Target: HPV16 E6

Host Species: Mouse

Target Species: Human Papillomavirus Type 16 (HPV16),

Application: ELISA,

Recombinant Anti-HPV16 E6 Antibody (V3S-0522-YC3770) (CAT#: V3S-0522-YC3770)

Target: HPV16 E6

Host Species: Mouse

Target Species: Human Papillomavirus Type 16 (HPV16),

Application: ELISA,

Recombinant Anti-HPV16 E6 Antibody (V3S-0522-YC3771) (CAT#: V3S-0522-YC3771)

Target: HPV16 E6

Host Species: Mouse

Target Species: Human Papillomavirus Type 16 (HPV16),

Application: ELISA,

Recombinant Anti-HPV16 E6 Antibody (V3S-0522-YC3772) (CAT#: V3S-0522-YC3772)

Target: HPV16 E6

Host Species: Mouse

Target Species: Human Papillomavirus Type 16 (HPV16),

Application: ELISA,

Recombinant Anti-HPV16 E6 Antibody (V3S-0522-YC3773) (CAT#: V3S-0522-YC3773)

Target: HPV16 E6

Host Species: Mouse

Target Species: Human Papillomavirus Type 16 (HPV16),

Application: ELISA,

Recombinant Anti-HPV16 E6 Antibody (V3S-0522-YC3788) (CAT#: V3S-0522-YC3788)

Target: HPV16 E6

Host Species: Mouse

Target Species: Human Papillomavirus Type 16 (HPV16),

Application: ELISA,

Recombinant Anti-HPV16 E6 Antibody (V3S-0522-YC3810) (CAT#: V3S-0522-YC3810)

Target: HPV16 E6

Host Species: Mouse

Target Species: Human Papillomavirus Type 16 (HPV16),

Application: ELISA,

Recombinant Anti-HPV16 E6 Antibody (V3S-0522-YC3811) (CAT#: V3S-0522-YC3811)

Target: HPV16 E6

Host Species: Mouse

Target Species: Human Papillomavirus Type 16 (HPV16),

Application: ELISA,

For research use only, not directly for clinical use.

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