H1N1 Specific Neutra™ Antibody Products

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Influenza A (H1N1) ranks among influenza A's most impactful subtypes, causing respiratory illnesses from routine seasonal cases to critical pneumonia. Most infections start abruptly with fever spikes, dry hacking coughs, and total-body muscle fatigue - classic flu symptoms resolving within days for healthy adults. High-risk groups tell a different story: seniors over 65, children under five, and immuno-compromised patients frequently develop complications like bacterial pneumonia or ARDS. Winter months drive predictable surges in temperate zones, though pandemic risks persist (2009 demonstrated global spread capacity). Transmission hinges on two pathways: inhaling cough-generated droplets or touching contaminated surfaces like doorknobs, where the virus survives 24-48 hours. Creative Biolabs offers a range of high-quality anti-H1N1 neutralizing antibody products. With years of experience, our products provide reliable and effective solutions for H1N1 research and development.

H1N1 Genome and Structure

Unlike many viruses with single genetic strands, H1N1 carries its blueprint in eight separate RNA segments. These code for proteins that form the virus's structure and infection machinery and are packaged within a virion. Two surface proteins, hemagglutinin (HA) and neuraminidase (NA), are crucial for the virus's infectious cycle. HA mediates virus attachment to sialic acid receptors on host cell surfaces, so initiating the infection process. NA promotes the release of newly produced virions from infected cells, which allows the virus to spread to additional cells. The specific combination of HA type 1 and NA type 1 defines this H1N1 subtype. This segmented design allows genetic mixing when different flu strains infect the same host - a key reason new variants keep emerging. Structural proteins like matrix (M1/M2) maintain viral shape, while nucleoproteins (NP) protect genetic material during transmission.

H1N1 enveloped virus with outer lipid membrane having glycoprotein 'spikes'.Fig. 1 Schematic of H1N1.Distributed under CC BY-SA 4.0, from Wiki, without modification.

Pathophysiology of H1N1

The virus attacks through two simultaneous mechanisms. First, it directly destroys respiratory cells during replication. Second, it triggers an immune overreaction - the body's defense chemicals (cytokines) flood lung tissue, causing fluid buildup and oxygen deprivation. This double assault explains why some patients rapidly develop life-threatening complications despite antiviral treatment. Outcomes depend heavily on individual factors: children's developing immune systems often overreact, while elderly patients may lack the immune reserves to counter aggressive viral strains.

Mechanisms of HIN1-induced asthma. (OA Literature)Fig. 2 H1N1 virus and asthma.1

Histopathology of H1N1

Microscopic analysis of infected individuals reveals three consistent lung changes: fluid-filled air sacs (alveoli), glassy protein deposits lining airways, and dense immune cell clusters. The respiratory lining shows extensive cell death, impairing oxygen exchange. Severe cases present consolidated lung tissue resembling soaked sponge texture, sometimes with visible bleeding. Secondary bacterial infections add pus-filled pockets and distinct inflammation markers. These tissue changes directly correlate with disease progression, with more pronounced and extensive changes observed in fatal cases.

Antibodies Targeting H1N1

Antibodies play a critical role in the adaptive immune response to H1N1 infection. Effective immune responses focus antibodies on HA's receptor-binding sites - the virus's cellular entry points. Successful antibody binding physically inhibits viral attachment, preventing both initial infection and cell-to-cell spread. Vaccine development aims to stimulate antibodies recognizing these critical regions, while therapeutic antibodies mimic the blocking function. Maintaining sufficient antibody levels proves crucial, explaining why immunity fades over time and why high-risk groups often require booster shots.

The synergistic effect of a combination treatment of different therapeutic targets to different stages of influenza viral life cycles. (OA Literature)Fig. 3 Proposed model of the synergistic antiviral mechanism of neutralizing antibody.2

REFERENCES

  1. Obuchi, Masatsugu, et al. "Influenza A (H1N1) pdm09 virus and asthma." Frontiers in Microbiology 4 (2013): 307. Distributed under Open Access license CC BY 3.0, without modification.
  2. Hoang, Phuong Thi, et al. "A synergistic therapy against influenza virus A/H1N1/PR8 by a HA1 specific neutralizing single-domain VL and an RNA hydrolyzing scFv." Frontiers in Microbiology 15 (2024): 1355599. Distributed under Open Access license CC BY 4.0, without modification.
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Anti-IAV H1N1 Neutralizing Antibody (V3S-0622-YC3426) (CAT#: V3S-0622-YC3426)

Target: IAV H1N1

Host Species: Human

Target Species: Influenza A virus (IAV),

Application: ELISA,Neut,

For research use only, not directly for clinical use.


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