ICOSLG Specific Neutra™ Antibody Products

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Inducible T cell costimulator ligand (ICOSLG), also known as B7H and CD275, is a single-pass type I membrane protein. This protein is a ligand of ICOS, a T-cell-specific cell surface receptor. The ICOS-ICOSLG pathway has important clinical significance for the immune system.

Its Gene ID is 23308, OMIM ID is 605717, and UniProtKB ID is O75144.

ICOS-ICOSLG Signaling Pathway

Attracting cognate Tfh cells and engaging in T-B collaboration is critical for the differentiation of GC B cells. Here we list the role of the ICOS-ICOSL pathway under conditions with or without TCR engagement in Tfh migration and T-B collaboration.

Transient and repetitive ligation of the ICOS-ICOSL without TCR engagement functions as the following (Figure 1A):

  • Induces transient actin remodeling, which involves programming and motility of T follicular helper (Tfh) cells.
  • Facilitates cognate T-B conjugation and its entry into the germinal center (GC) of lymphoid organs to generate high-affinity antibodies.

Ligation of ICOS-ICOSL with TCR engagement in the TCR and peptide-MHC complex works as follows (Figure 1B):

  • Facilitates CD40L externalization causing CD40 co-stimulation to GC-B cells.
  • Increases translation of IL-4 mRNA and accurately delivers CD40L and IL-4 for effective selection of GC-B cell clones with high affinity for the internalized cognate antigens.

ICOS-ICOSLG signal transduction during Tfh migration and T-B collaboration. (Panneton, et al., 2019) Fig.1 ICOS-ICOSLG signal transduction during Tfh migration and T-B collaboration.1

Clinical Significance of ICOSLG

ICOS and ICOSLG are closely associated with various diseases, such as colorectal cancer, acute lymphoblastic leukemia, autoimmune diseases, immunodeficiency, and other inflammatory diseases. Therefore, ICOS-ICOSLG signaling is a promising biomarker and target for immunodiagnosis, prognosis, and therapy.

  • In preclinical or clinical studies, the agonistic antibodies targeting the ICOS-ICOSLG pathway could induce tumor regression through the regulation of T-cell immunity. These antagonistic antibodies have been used for cancer treatment.
  • The rationale study about this signal reveals that the ICOS-ICOSLG pathway may help improve vaccine prevention and immunotherapy treatment of immune disorder diseases and cancers.

Creative Biolabs offers a comprehensive range of high-quality anti-ICOSLG antibodies to assist research studies of our customers.

Reference

  1. Panneton, Vincent.; et al. "Inducible T-cell co-stimulator: signaling mechanisms in T follicular helper cells and beyond." Immunological Reviews 291.1 (2019): 91-103.
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Anti-ICOSLG Neutralizing Antibody (V3S-0622-YC1044) (CAT#: V3S-0622-YC1044)

Target: ICOSLG

Host Species: Mouse

Target Species: Human,

Application: FuncS,

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Recombinant Anti-ICOSLG Antibody (V3S-0622-YC3443) (CAT#: V3S-0622-YC3443)

Target: ICOSLG

Host Species: Human

Target Species: Human,

Application: ELISA,

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Recombinant Anti-ICOSLG Antibody (V3S-0622-YC3444) (CAT#: V3S-0622-YC3444)

Target: ICOSLG

Host Species: Human

Target Species: Human,

Application: ELISA,

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Recombinant Anti-ICOSLG Antibody (V3S-0622-YC3445) (CAT#: V3S-0622-YC3445)

Target: ICOSLG

Host Species: Human

Target Species: Human,

Application: ELISA,

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Recombinant Anti-ICOSLG Antibody (V3S-0622-YC3446) (CAT#: V3S-0622-YC3446)

Target: ICOSLG

Host Species: Human

Target Species: Human,

Application: ELISA,

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Recombinant Anti-ICOSLG Antibody (V3S-0622-YC3447) (CAT#: V3S-0622-YC3447)

Target: ICOSLG

Host Species: Human

Target Species: Human,

Application: ELISA,

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Recombinant Anti-ICOSLG Antibody (V3S-0622-YC3448) (CAT#: V3S-0622-YC3448)

Target: ICOSLG

Host Species: Human

Target Species: Human,

Application: ELISA,

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Anti-ICOSLG Neutralizing Antibody (V3S-0522-YC1472) (CAT#: V3S-0522-YC1472)

Target: ICOSLG

Host Species: Human

Target Species: Human,

Application: ELISA,IHC,FC,IP,IF,Inhib,

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Anti-ICOSLG Neutralizing Antibody (V3S-0822-YC1311) (CAT#: V3S-0822-YC1311)

Target: ICOSLG

Host Species: Mouse

Target Species: Human,

Application: Neut,WB,

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Anti-ICOSLG Neutralizing Antibody (V3S-0822-YC1312) (CAT#: V3S-0822-YC1312)

Target: ICOSLG

Host Species: Mouse

Target Species: Human,

Application: Neut,WB,

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Anti-ICOSLG Neutralizing Antibody (V3S-0822-YC1313) (CAT#: V3S-0822-YC1313)

Target: ICOSLG

Host Species: Mouse

Target Species: Human,

Application: Neut,WB,

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Anti-ICOSLG Neutralizing Antibody (V3S-0822-YC1314) (CAT#: V3S-0822-YC1314)

Target: ICOSLG

Host Species: Mouse

Target Species: Human,

Application: FC,CyTOF,Neut,

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Anti-ICOSLG (aa 19-258) Neutralizing Antibody (V3S-0822-YC1315) (CAT#: V3S-0822-YC1315)

Target: ICOSLG

Host Species: Mouse

Target Species: Human,

Application: Neut,ELISA,WB,

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Anti-ICOSLG (aa 19-258) Neutralizing Antibody (V3S-0822-YC1316) (CAT#: V3S-0822-YC1316)

Target: ICOSLG

Host Species: Mouse

Target Species: Human,

Application: Neut,FC,WB,ELISA,

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Anti-ICOSLG Neutralizing Antibody (V3S-0822-YC1317) (CAT#: V3S-0822-YC1317)

Target: ICOSLG

Host Species: Mouse

Target Species: Human,

Application: FC,FuncS,IHC-Fr,Neut,

For research use only, not directly for clinical use.


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