IGF1 Specific Neutra™ Antibody Products
Product listAccelerate Your Research and Development!
Creative Biolabs’ IGF1 antibodies provide exceptional detection specificity, precise quantification, and robust tools for intricate pathway analysis and disease mechanism elucidation. Our solutions are designed to overcome common challenges in IGF1 research, ensuring reliable and reproducible results for your critical experiments. Whether you are investigating growth and development, metabolic disorders, neurological conditions, or cancer, our antibodies offer the precision required to advance your scientific understanding.
Contact our team to get an inquiry now!
Introduction of IGF1
Insulin-like Growth Factor 1 (IGF1) is a crucial polypeptide hormone, structurally and functionally similar to insulin, playing a pivotal role in diverse physiological processes from fetal development to adult tissue homeostasis. Comprising 70 amino acids and with a molecular weight of 7649 Da, IGF1 is primarily synthesized by the liver in response to growth hormone (GH). However, locally produced non-hepatic IGF1, acting through paracrine and autocrine mechanisms, is a significant driver of its postnatal growth-promoting effects.
IGF1 exerts widespread anabolic effects, promoting systemic body growth and regulating cellular proliferation, differentiation, migration, and survival throughout the body. This includes critical roles in skeletal muscle, cartilage, bone, liver, kidney, nerve, skin, hematopoietic, and lung cells. Its profound influence on cellular functions makes it a central player in various biological systems.
Fig. 1 The role of IGF-1 signaling in breast cancer development and metastasis.1
The intricate balance of IGF1 levels and signaling is critical for health, and imbalances are associated with various disease states. Low circulating IGF1 levels have been linked to conditions such as cardiovascular disease and neurodegenerative disorders like Alzheimer's disease, suggesting its protective roles. Conversely, elevated serum IGF1 concentrations associate with increased risk for common cancers like breast, colorectal, and prostate malignancies. In oncology, dysregulated IGF1 signaling pathways are implicated in cancer initiation, progression, and metastasis. Specific IGF1 isoforms, such as IGF-1Ea and IGF-1Eb, promote cell proliferation and survival, while IGF-1Ec has been shown to enhance cellular proliferation, migration, and invasion by promoting the Epithelial-Mesenchymal Transition (EMT) process, contributing to metastasis. The complex interplay of IGF1 with other growth factors and receptors, such as estrogen receptors (ER) in breast cancer, further underscores its multifaceted role in disease pathophysiology.
Antibodies Against IGF1
Antibodies against IGF1 are indispensable tools for researchers investigating this vital growth factor in health and disease. These highly specific reagents enable IGF1 detection, quantification, and functional manipulation across various biological samples and experimental systems. Creative Biolabs offers a comprehensive range of meticulously validated IGF1 specific antibodies, ensuring superior performance across multiple applications.
Applications of IGF1 Antibodies:
- Western Blot (WB): Detects and quantifies IGF1 protein levels in cell lysates or tissue homogenates, allowing researchers to confirm presence, expression, post-translational modifications, and regulation under various conditions.
- Immunohistochemistry (IHC) & Immunocytochemistry (ICC): These techniques use IGF1 antibodies to visualize IGF1's cellular and subcellular localization within tissue sections (IHC) or cultured cells (ICC), providing critical spatial information on its expression.
- Enzyme-Linked Immunosorbent Assay (ELISA): A quantitative method for measuring IGF1 concentrations in biological fluids like serum or plasma. ELISA kits offer high-throughput, sensitive monitoring of IGF1 levels, serving as a biomarker for health and disease progression.
- Flow Cytometry (FC): Enables detection and quantification of IGF1 expression on cell surfaces or within specific cell populations. This is useful for analyzing heterogeneous samples, identifying expressing cells, and studying expression changes in response to stimuli or disease.
- Functional Studies (e.g., Neutralization / Blocking): Specific IGF1 antibodies neutralize or block IGF1's biological activity by preventing receptor binding. These are invaluable for in vitro and in vivo studies to understand IGF1's precise roles in cellular processes, disease models, and therapeutic interventions.
Creative Biolabs’ IGF1 antibodies are developed emphasizing specificity, sensitivity, and reproducibility. We offer diverse antibody types (monoclonal, polyclonal, recombinant) and host species, ensuring compatibility with various experimental setups and research needs. Our rigorous validation, including neutralization assays, guarantees reliable and accurate results for your most demanding research.
Why Choose Us?
Choosing Creative Biolabs means partnering with a leader committed to scientific excellence and customer success, with products engineered for superior performance and reliable results.
- Unrivaled Specificity: Our IGF1 antibodies are rigorously validated via neutralization assays for highly specific detection of IGF1 and its isoforms, critical for accurate research.
- Broad Application Versatility: Optimized for diverse applications (WB, IHC, ELISA, ICC, FC), Creative Biolabs’ IGF1 antibodies offer flexibility for varied experimental needs.
- Comprehensive Portfolio: We provide a diverse selection of IGF1 antibodies, including monoclonal, polyclonal, and recombinant options from various host species, ensuring the perfect fit for your research.
- Robust Validation: Every antibody undergoes stringent quality control and validation, with specificity confirmed through multiple assays and cross-species testing, supported by extensive Published Data.
- Expert Technical Support: Our dedicated scientific experts offer comprehensive assistance for protocol optimization and troubleshooting, ensuring you achieve the best results.
- Consistent Performance: Exceptional batch-to-batch consistency guarantees reliable, reproducible data across all your experiments.
FAQs
Here are some common questions from researchers interested in IGF1 specific antibody products:
Q: How do I choose the right IGF1 antibody for my specific research application?
A: Selecting the ideal IGF1 antibody depends on your experimental goals and the technique you plan to use. Creative Biolabs provides detailed datasheets for each antibody, specifying validated applications (e.g., WB, IHC, ELISA), species reactivity, and recommended dilutions. Our technical support team is also available to offer personalized recommendations based on your specific sample type and research objectives. Don't hesitate to reach out for tailored guidance!
Q: What validation data supports the specificity and reliability of Creative Biolabs’ IGF1 antibodies?
A: Creative Biolabs is committed to rigorous quality control. Our IGF1 antibodies undergo extensive validation, including Western blot analysis with recombinant IGF1 and tissue/cell lysates, immunohistochemistry on known positive and negative tissues, and neutralization assays to confirm specific binding. We also provide comprehensive data on lot-to-lot consistency. This robust validation ensures high specificity and minimal off-target binding, giving you confidence in your results.
Q: Can Creative Biolabs’ IGF1 antibodies be used for functional studies, such as blocking IGF1 signaling?
A: Yes, Creative Biolabs offers specific IGF1 antibodies that have been validated for functional applications, including neutralization or blocking studies. These antibodies can inhibit IGF1's binding to its receptor, allowing you to investigate the precise role of IGF1 in various cellular processes, such as proliferation, differentiation, or survival. Look for "neutralizing" or "blocking" claims on our product datasheets, or inquire with our team for more details.
Access the Creative Biolabs Edge – Request Your Quote Now
REFERENCE
- Kotsifaki, Amalia et al. “Decoding the Role of Insulin-like Growth Factor 1 and Its Isoforms in Breast Cancer.” International journal of molecular sciences vol. 25,17 9302. 27 Aug. 2024, DOI:10.3390/ijms25179302. Distributed under Open Access license CC BY 4.0, without modification.
