IL4 Specific Neutra™ Antibody Products
Product listInterleukin 4 (IL4), also known as BCGF1 or BSF1, is a common cytokine. Similar to other cytokines, IL-4 has a typical globular folded structure. IL4 can be produced by various cells, including Th2 cells, eosinophils cells as well as mast cells. IL4 has been implicated in immune regulation, such as stimulating the proliferation of activated B cells and T cells, and the differentiation of B cells into plasma cells. Therefore, IL4 is an essential regulator of humoral and adaptive immunity.
Its Gene ID: 3565, UniProtKB ID: P05112, and OMIM ID: 147780.
IL4/IL4 Receptor (IL4R) Signaling Axis
IL-4 exerts its functions by interacting with two IL4 receptor complexes. Once the ligand binds, IL4 receptor dimerization induces activation of Janus kinase (JAK) family proteins, which phosphorylate IL4R, alpha (IL4Ra), leading to activation of other pathways, such as insulin receptor substrate protein (IRS)/PI3K/AKT pathway. Studies have revealed that IL4Ra is closely linked to increased activation of STAT6, AKT, and ERK in breast cancer.
Fig.1 IL-4/IL-13 axis and their signaling transduction.1
Related Diseases
Increasing evidence indicates that IL4 is closely linked to various autoimmune diseases. IL4 has also been shown to have a significant impact on the progression of several tumors, such as prostate, breast, and lung cancer. Additionally, IL-4 may also serve as a critical regulator in the infection and progression of HIV disease, and it has also been found to alleviate inflammation and neuropathic pain. IL-4 is also involved in the regulation of retinal progenitor cell proliferation. Notably, evidence has revealed the regulatory role of IL-4 in a variety of nervous system diseases, such as multiple sclerosis and Alzheimer's disease.
Fig.2 Tumor microenvironment and role of IL-4/IL-13 in tumor development.1
Blocking IL4 Activity with Specific Neutralizing Antibody
The IL4/IL4R signaling axis can effectively promote epithelial cancer cell proliferation, migration, and survival. Selecting neutralizing antibodies specific for IL4 is effective in controlling metastatic tumor growth. Creative Biolabs offers dozens of different anti-IL4 antibodies. These antibodies are recombinantly expressed and are suitable for a variety of experiments, including WB, ELISA, FC, and IP. In addition, a variety of antibodies modified with fluorescent groups and biotin are also available.
REFERENCE
- Shi, Jingwei, et al. "Involvement of IL-4, IL-13 and their receptors in pancreatic cancer." International journal of molecular sciences 22.6 (2021): 2998.
