Interleukin-4

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The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation. This cytokine has been reported to promote resolution of neutrophil-mediated acute lung injury. In an allergic response, IL-4 has an essential role in the production of allergen-specific immunoglobin (Ig) E. This pro-inflammatory cytokine has been observed to be increased in COVID-19 (Coronavirus disease 2019) patients, but is not necessarily associated with severe COVID-19 pathology. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
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Recombinant Anti-IL4 Antibody (V3S-0622-YC4752) (CAT#: V3S-0622-YC4752)

Target: IL4

Host Species: Mouse

Target Species: Human,

Application: ELISA,FC,

Inquiry

Anti-IL4 Neutralizing Antibody (V3S-0622-YC4753) (CAT#: V3S-0622-YC4753)

Target: IL4

Host Species: Human

Target Species: Human,

Application: DB,WB,ELISA,FC,IP,FuncS,IF,Neut,

Inquiry

Recombinant Anti-IL4 Antibody (V3S-0522-YC2454) (CAT#: V3S-0522-YC2454)

Target: IL4

Host Species: Mouse

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-IL4 Antibody (V3S-0522-YC2455) (CAT#: V3S-0522-YC2455)

Target: IL4

Host Species: Human

Target Species: Human,

Application: ELISA,

Inquiry

Anti-IL4 Neutralizing Antibody (V3S-0522-YC2456) (CAT#: V3S-0522-YC2456)

Target: IL4

Host Species: Mouse

Target Species: Human,

Application: Block,FuncS,

Inquiry

Anti-IL4 Neutralizing Antibody (V3S-0522-YC2457) (CAT#: V3S-0522-YC2457)

Target: IL4

Host Species: Human

Target Species: Human,

Application: Antagonist,

Inquiry

Anti-IL4 (aa 25-132) Neutralizing Antibody (V3S-0822-YC1764) (CAT#: V3S-0822-YC1764)

Target: IL4

Host Species: Mouse

Target Species: Dog,

Application: Neut,

Inquiry

Anti-IL4 (aa 25-133) Neutralizing Antibody (V3S-0822-YC1765) (CAT#: V3S-0822-YC1765)

Target: IL4

Host Species: Mouse

Target Species: Cat,

Application: WB,ELISA,Neut,

Inquiry

Anti-IL4 Neutralizing Antibody (V3S-0822-YC1766) (CAT#: V3S-0822-YC1766)

Target: IL4

Host Species: Mouse

Target Species: Human,

Application: ELISA,Neut,WB,

Inquiry

Anti-IL4 Neutralizing Antibody (V3S-0822-YC1767) (CAT#: V3S-0822-YC1767)

Target: IL4

Host Species: Rabbit

Target Species: Human,

Application: Neut,

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Anti-IL4 Neutralizing Antibody (V3S-0822-YC1768) (CAT#: V3S-0822-YC1768)

Target: IL4

Host Species: Rat

Target Species: Human,

Application: Block,ELISA,IHC,WB,

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Anti-IL4 Neutralizing Antibody (V3S-0822-YC1769) (CAT#: V3S-0822-YC1769)

Target: IL4

Host Species: Mouse

Target Species: Human,

Application: ICC,IF,Neut,WB,

Inquiry

Anti-IL4 Neutralizing Antibody (V3S-0822-YC1770) (CAT#: V3S-0822-YC1770)

Target: IL4

Host Species: Mouse

Target Species: Human,

Application: IHC-Fr,ELISA,ELISpot,Neut,

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Anti-IL4 Neutralizing Antibody (V3S-0822-YC1771) (CAT#: V3S-0822-YC1771)

Target: IL4

Host Species: Mouse

Target Species: Human, Chimpanzee, Baboon, Cynomolgus, Rhesus,

Application: ELISA,ELISpot,Neut,ICFC,IHC,IP,

Inquiry

Anti-IL4 Neutralizing Antibody (V3S-0822-YC1772) (CAT#: V3S-0822-YC1772)

Target: IL4

Host Species: Mouse

Target Species: Human,

Application: FC,ICC,IF,Neut,WB,

Inquiry

Anti-IL4 Neutralizing Antibody (V3S-0822-YC1773) (CAT#: V3S-0822-YC1773)

Target: IL4

Host Species: Mouse

Target Species: Human,

Application: Neut,WB,IHC,

Inquiry

Anti-IL4 Neutralizing Antibody (V3S-0822-YC1774) (CAT#: V3S-0822-YC1774)

Target: IL4

Host Species: Mouse

Target Species: Human,

Application: WB,ICC,Neut,

Inquiry

Anti-IL4 Neutralizing Antibody (V3S-0822-YC1775) (CAT#: V3S-0822-YC1775)

Target: IL4

Host Species: Rat

Target Species: Mouse, Rat,

Application: Neut,WB,

Inquiry

Anti-IL4 Neutralizing Antibody (V3S-0822-YC1776) (CAT#: V3S-0822-YC1776)

Target: IL4

Host Species: Mouse

Target Species: Human,

Application: Neut,WB,

Inquiry

Anti-IL4 Neutralizing Antibody (V3S-0822-YC1777) (CAT#: V3S-0822-YC1777)

Target: IL4

Host Species: Rat

Target Species: Human,

Application: ELISA,FC,IF,Neut,WB,

Inquiry

Anti-IL4 Neutralizing Antibody (V3S-0822-YC1778) (CAT#: V3S-0822-YC1778)

Target: IL4

Host Species: Human

Target Species: Human,

Application: Neut,

Inquiry

Anti-IL4 Neutralizing Antibody (V3S-0822-YC1779) (CAT#: V3S-0822-YC1779)

Target: IL4

Host Species: Mouse

Target Species: Human,

Application: Neut,WB,IHC,IHC-Fr,

Inquiry

Anti-IL4 Neutralizing Antibody (V3S-0822-YC1795) (CAT#: V3S-0822-YC1795)

Target: IL4

Host Species: Mouse

Target Species: Pig,

Application: Neut,

Inquiry

Anti-IL4 Neutralizing Antibody (V3S-0822-YC1796) (CAT#: V3S-0822-YC1796)

Target: IL4

Host Species: Mouse

Target Species: Rabbit,

Application: Neut,

Inquiry

Anti-IL4 Neutralizing Antibody (V3S-0822-YC2744) (CAT#: V3S-0822-YC2744)

Target: IL4

Host Species: Rat

Target Species: Human,

Application: Neut,FC,

Inquiry

Recombinant Anti-IL4 Antibody (V3S-0723-FY39) (CAT#: V3S-0723-FY39)

Target: IL4

Host Species: Human

Target Species: Human,

Application: ELISA,FuncS,

Inquiry

Anti-Il4 Neutralizing Antibody (V3S-0822-YC1781) (CAT#: V3S-0822-YC1781)

Target: Il4

Host Species: Rat

Target Species: Mouse,

Application: Neut,ELISA,IP,

Inquiry

Anti-Il4 Neutralizing Antibody (V3S-0822-YC1782) (CAT#: V3S-0822-YC1782)

Target: Il4

Host Species: Rat

Target Species: Mouse,

Application: Neut,WB,

Inquiry

Recombinant Anti-Il4 Antibody (V3S-0822-YC1783) (CAT#: V3S-0822-YC1783)

Target: Il4

Host Species: Rat

Target Species: Mouse,

Application: ELISA,FC,ICC,NT,

Inquiry

Anti-Il4 Neutralizing Antibody (V3S-0822-YC1784) (CAT#: V3S-0822-YC1784)

Target: Il4

Host Species: Rat

Target Species: Mouse,

Application: WB,ELISA,Neut,

Inquiry

Anti-Il4 Neutralizing Antibody (V3S-0822-YC1785) (CAT#: V3S-0822-YC1785)

Target: Il4

Host Species: Rat

Target Species: Mouse,

Application: Block,DB,

Inquiry

Anti-Il4 Neutralizing Antibody (V3S-0822-YC1786) (CAT#: V3S-0822-YC1786)

Target: Il4

Host Species: Rat

Target Species: Mouse,

Application: FC,IHC-Fr,IP,Neut,

Inquiry

Anti-Il4 Neutralizing Antibody (V3S-0822-YC1787) (CAT#: V3S-0822-YC1787)

Target: Il4

Host Species: Rat

Target Species: Mouse,

Application: Neut,WB,

Inquiry

Anti-Il4 Neutralizing Antibody (V3S-0822-YC1788) (CAT#: V3S-0822-YC1788)

Target: Il4

Host Species: Rat

Target Species: Mouse,

Application: FC,IHC,IP,Neut,

Inquiry

Anti-Il4 Neutralizing Antibody (V3S-0822-YC1789) (CAT#: V3S-0822-YC1789)

Target: Il4

Host Species: Rat

Target Species: Mouse,

Application: ELISA,Neut,

Inquiry

Anti-Il4 Neutralizing Antibody (V3S-0822-YC1790) (CAT#: V3S-0822-YC1790)

Target: Il4

Host Species: Rat

Target Species: Mouse,

Application: ELISA,FC,IF,Neut,WB,

Inquiry

Anti-Il4 Neutralizing Antibody (V3S-0822-YC1791) (CAT#: V3S-0822-YC1791)

Target: Il4

Host Species: Mouse

Target Species: Mouse,

Application: Neut,ELISA,

Inquiry

Anti-Il4 Neutralizing Antibody (V3S-0822-YC1792) (CAT#: V3S-0822-YC1792)

Target: Il4

Host Species: Rat

Target Species: Mouse,

Application: ELISA,CyTOF,ELISpot,Neut,ICC,IP,IHC,

Inquiry

Anti-Il4 Neutralizing Antibody (V3S-0822-YC1793) (CAT#: V3S-0822-YC1793)

Target: Il4

Host Species: Rat

Target Species: Mouse, Rat,

Application: Block,ELISA,FC,ICC,IF,WB,

Inquiry

Anti-Il4 Neutralizing Antibody (V3S-0822-YC1794) (CAT#: V3S-0822-YC1794)

Target: Il4

Host Species: Rat

Target Species: Mouse, Rat,

Application: Block,ELISA,ICC,IF,IHC,WB,

For research use only, not directly for clinical use.


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