Kaposi's sarcoma-associated herpesvirus viral interleukin-6

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Viral interleukin-6 (vIL-6) is a product of Kaposi's sarcoma-associated herpesvirus (KSHV) expressed in latently infected cells and to a higher degree during viral replication. A distinctive feature of vIL-6 is the ability to directly bind and activate gp130 signaling in the absence of other receptor subunits. Secretion of vIL-6 is generally poor, but vIL-6 can activate gp130 from inside the cell. Due to the wide cell distribution of gp130, vIL-6 has the potential to induce a wide range of biological effects. Expression of vIL-6 is variable in KSHV-associated Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), multicentric Castleman's disease (MCD), and in a newly described MCD-like systemic inflammatory syndrome observed in human immunodeficiency virus-positive patients.

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Recombinant Anti-KSHV vIL-6 Antibody (V3S-0522-YC3819) (CAT#: V3S-0522-YC3819)

Target: KSHV vIL-6

Host Species: Mouse

Target Species: Kaposi's Sarcoma-associated Herpesvirus (KSHV),

Application: ELISA,