L. monocytogenes Specific Neutra™ Antibody Products

Accelerate Your Research and Development!

Creative Biolabs’ L. monocytogenes Specific Antibody Products provide precise and reliable tools essential for the identification and quantification of this critical foodborne pathogen. Our solutions empower you to implement robust monitoring programs, accelerate outbreak investigations, and ensure compliance with global food safety standards. We deliver components that are critical for developing highly sensitive and specific diagnostic assays, enabling proactive control and prevention strategies within your food production environment.

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Introduction of L. monocytogenes

Listeria monocytogenes is a Gram-positive, facultative anaerobic bacterium notorious for its exceptional ability to survive and thrive across a wide spectrum of environmental conditions. As the causative agent of listeriosis, a severe foodborne illness, it poses a significant global public health concern, particularly due to its high hospitalization and mortality rates (20-30%), especially among vulnerable populations.

Fig. 1 The intracellular life cycle of L. monocytogenes.¹

This pathogen's hardiness originates from its ability to thrive at refrigeration temperatures (0.4–45°C), survive across pH 4.6–9.5, withstand elevated salinity levels, and establish persistent biofilm communities in food processing environments. These microbial aggregates create sheltered microenvironments, rendering L. monocytogenes resistant to elimination through routine disinfection protocols. Its distinct intracellular survival strategy facilitates evasion of immune defenses, utilizing virulence proteins including internalins (InlA / InlB) for cellular entry, listeriolysin O (LLO) for cytoplasmic liberation, and ActA for cytoskeletal propulsion, facilitating intercellular transmission. These evolved adaptations highlight why accurate detection methods are critical for blocking its propagation across food supply networks.

Antibodies Against L. monocytogenes

Antibodies against L. monocytogenes are indispensable tools in modern food safety and clinical diagnostics, providing highly specific and sensitive detection capabilities that complement or surpass traditional culture methods. These antibodies are designed to recognize distinct antigenic determinants on the bacterial surface or its secreted virulence factors, allowing for targeted identification.

Applications of L. monocytogenes Antibodies:

Our antibodies are rigorously validated for various applications crucial in food safety and research:

• Enzyme-Linked Immunosorbent Assay (ELISA): Both monoclonal and polyclonal antibodies are widely used in ELISA for rapid and sensitive detection of L. monocytogenes in food and environmental samples. Monoclonal antibodies are particularly effective as capture or detection antibodies in sandwich ELISA formats for high-throughput screening.
• Western Blot (WB): Antibodies are used to detect specific L. monocytogenes proteins, including virulence factors, by separating bacterial proteins by size and transferring them to a membrane.
• Immunohistochemistry (IHC) & Immunofluorescence (IF): These techniques allow for the visualization of L. monocytogenes directly in tissue sections or on environmental surfaces, aiding in understanding colonization patterns and biofilm formation.
• Rapid Test Kits (e.g., Lateral Flow Devices): High-specificity antibodies are the core component of rapid immunoassay strips, enabling on-site, quick screening of samples for presumptive L. monocytogenes presence, crucial for urgent decision-making in food processing.
• Flow Cytometry: Monoclonal antibodies labeled with fluorochromes can be used for the rapid enumeration and differentiation of L. monocytogenes from other bacteria in complex samples.

By providing highly characterized antibodies, Creative Biolabs supports the development of robust diagnostic solutions that contribute significantly to proactive food safety management and public health protection.

Why Choose Us?

Creative Biolabs serves as your dedicated collaborator for superior-grade L. monocytogenes-targeting antibodies, providing unmatched quality, reproducibility, and specialized assistance. Our devotion to research excellence and customer achievement distinguishes us.

• Superior Specificity & Sensitivity: Our antibodies are meticulously developed and validated to offer exceptional specificity for L. monocytogenes, minimizing cross-reactivity with other Listeria species or food matrix components. This ensures highly accurate and reliable detection, critical for preventing false positives and negatives.
• Rigorous Quality Control: Every batch undergoes extensive quality control testing, including ELISA, Western Blot, and often application-specific functional assays, to guarantee lot-to-lot consistency and optimal performance.
• Comprehensive Offerings: We supply diverse L. monocytogenes antibodies spanning monoclonal–polyclonal formats and labeled variants (e.g., FITC, Biotin), enabling optimal selection for tailored immunoassay development.
• Expert Technical Support: Our team of experienced microbiologists and immunologists provides unparalleled technical assistance, from product selection and experimental design to troubleshooting and optimization.

FAQs

Here are some common questions from researchers and developers interested in L. monocytogenes Specific Antibody Products:

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REFERENCE

1. Bierne, Hélène et al. “To Be Cytosolic or Vacuolar: The Double Life of Listeria monocytogenes.” Frontiers in cellular and infection microbiology vol. 8 136. 15 May. 2018, DOI:10.3389/fcimb.2018.00136. Distributed under Open Access license CC BY 4.0, without modification.