LAG3 Specific NeutraTM Antibody Products

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Basic Information

  • Lymphocyte-activation gene 3 (LAG3), also known as CD223, encodes the inhibitory receptor lymphocyte activation gene 3 protein, binding to ligands, such as FGL1, and forms conserved signal interactions.
  • As an immune checkpoint, LAG3 is expressed primarily in activated T-cells and a subset of natural killer (NK) cells in tissues, such as the spleen and lymph nodes.
  • Interleukin-2, interleukin-7, or interleukin-12 induces the expression of LAG3 on activated T-cells. By binding to its ligands, LAG3 transmits an inhibitory signal, which further affects the immune function.
  • Its Gene ID is 3902, UniProtKB ID is P18627, and OMIM ID is 153337.

LAG3 Ligands

LAG-3 distinguishes and binds to pMHCII. Galectin-3 and LSECtin interact with LAG-3 on glycosylated sites and inhibit the IFN-γ production from T cells. FGL1 contributes to the inhibitory function of LAG-3 by reducing the secretion of IL-2.

Fig. 1 Structure and ligands of LAG3. (Ruffo, et al., 2019)Fig. 1 Structure and ligands of LAG3.1

Function

The functions of LAG3 in multiple diseases are listed below:

Fig. 2 Role of LAG3 on different T cell types. (Ruffo, et al., 2019)Fig. 2 Role of LAG3 on different T cell types.1

Clinical significance of LAG3

The crucial role of LAG-3 in the progression of tumor development highlights its therapeutic promise in anticancer immunity. LAG-3 has been extensively researched in animal models and clinical trials shown below.

Table 1 LAG-3-targeted immunotherapy.2

Table 1 LAG-3-targeted immunotherapy. (Maruhashi, et al., 2020)

REFERENCES

  1. Ruffo, Elisa, et al. "Lymphocyte-activation gene 3 (LAG3): The next immune checkpoint receptor." Seminars in immunology. Vol. 42. Academic Press, 2019.
  2. Maruhashi, Takumi, et al. "LAG-3: from molecular functions to clinical applications." Journal for immunotherapy of cancer 8.2 (2020).
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Anti-LAG3 Neutralizing Antibody (V3S-0622-YC330) (CAT#: V3S-0622-YC330)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: FC,Block,

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Anti-LAG3 Neutralizing Antibody (V3S-0622-YC331) (CAT#: V3S-0622-YC331)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: FC,Block,

Inquiry

Anti-LAG3 Neutralizing Antibody (V3S-0622-YC332) (CAT#: V3S-0622-YC332)

Target: LAG3

Host Species: Human

Target Species: Human, Cynomolgus, Baboon,

Application: FC,FuncS,

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Anti-LAG3 (ECD domain) Neutralizing Antibody (V3S-0622-YC2015) (CAT#: V3S-0622-YC2015)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: FuncS,

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Recombinant Anti-LAG3 Antibody (V3S-0622-YC3611) (CAT#: V3S-0622-YC3611)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,WB,

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Recombinant Anti-LAG3 Antibody (V3S-0622-YC3612) (CAT#: V3S-0622-YC3612)

Target: LAG3

Host Species: Human

Target Species: Human, Monkey,

Application: ELISA,WB,

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Recombinant Anti-LAG3 Antibody (V3S-0522-YC1825) (CAT#: V3S-0522-YC1825)

Target: LAG3

Host Species: Human

Target Species: Human, Mouse, Monkey,

Application: ELISA,FC,

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Recombinant Anti-LAG3 Antibody (V3S-0522-YC1826) (CAT#: V3S-0522-YC1826)

Target: LAG3

Host Species: Human

Target Species: Human, Mouse,

Application: ELISA,FC,

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Recombinant Anti-LAG3 Antibody (V3S-0522-YC1827) (CAT#: V3S-0522-YC1827)

Target: LAG3

Host Species: Human

Target Species: Human, Mouse,

Application: ELISA,FC,

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Recombinant Anti-LAG3 Antibody (V3S-0522-YC1828) (CAT#: V3S-0522-YC1828)

Target: LAG3

Host Species: Human

Target Species: Human, Mouse,

Application: ELISA,FC,

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Anti-LAG3 Neutralizing Antibody (V3S-0522-YC1858) (CAT#: V3S-0522-YC1858)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: Block,FC,

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Anti-LAG3 (ECD domain) Neutralizing Antibody (V3S-0522-YC1859) (CAT#: V3S-0522-YC1859)

Target: LAG3

Host Species: Human

Target Species: Human, Cynomolgus, Mouse,

Application: Block,FuncS,

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Anti-LAG3 Neutralizing Antibody (V3S-0822-YC2040) (CAT#: V3S-0822-YC2040)

Target: LAG3

Host Species: Mouse

Target Species: Human, Monkey,

Application: Neut,WB,ELISA,IF,IHC,IP,

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Anti-Lag3 Neutralizing Antibody (V3S-0822-YC2041) (CAT#: V3S-0822-YC2041)

Target: Lag3

Host Species: Rat

Target Species: Mouse,

Application: ELISA,FuncS,FC,IP,Neut,

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Recombinant Anti-LAG3 Antibody (V3S-1222-YC1651) (CAT#: V3S-1222-YC1651)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,

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Recombinant Anti-LAG3 Antibody (V3S-1222-YC1652) (CAT#: V3S-1222-YC1652)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,

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Recombinant Anti-LAG3 Antibody (V3S-1222-YC1653) (CAT#: V3S-1222-YC1653)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,

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Recombinant Anti-LAG3 Antibody (V3S-1222-YC1654) (CAT#: V3S-1222-YC1654)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,

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Recombinant Anti-LAG3 Antibody (V3S-1222-YC1655) (CAT#: V3S-1222-YC1655)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,

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Recombinant Anti-LAG3 Antibody (V3S-1222-YC1656) (CAT#: V3S-1222-YC1656)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-LAG3 Antibody (V3S-1222-YC1657) (CAT#: V3S-1222-YC1657)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-LAG3 Antibody (V3S-1222-YC1658) (CAT#: V3S-1222-YC1658)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-LAG3 Antibody (V3S-1222-YC1659) (CAT#: V3S-1222-YC1659)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-LAG3 Antibody (V3S-1222-YC1660) (CAT#: V3S-1222-YC1660)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,

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Recombinant Anti-LAG3 Antibody (V3S-1222-YC1662) (CAT#: V3S-1222-YC1662)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

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Recombinant Anti-LAG3 Antibody (V3S-1222-YC1663) (CAT#: V3S-1222-YC1663)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

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Recombinant Anti-LAG3 Antibody (V3S-1222-YC1664) (CAT#: V3S-1222-YC1664)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

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Recombinant Anti-LAG3 Antibody (V3S-1222-YC1665) (CAT#: V3S-1222-YC1665)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

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Recombinant Anti-LAG3 Antibody (V3S-1222-YC1666) (CAT#: V3S-1222-YC1666)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

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Recombinant Anti-LAG3 Antibody (V3S-1222-YC1667) (CAT#: V3S-1222-YC1667)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

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Recombinant Anti-LAG3 Antibody (V3S-1222-YC1668) (CAT#: V3S-1222-YC1668)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

Inquiry

Recombinant Anti-LAG3 Antibody (V3S-1222-YC1669) (CAT#: V3S-1222-YC1669)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

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Recombinant Anti-LAG3 Antibody (V3S-1222-YC1670) (CAT#: V3S-1222-YC1670)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

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Recombinant Anti-LAG3 Antibody (V3S-1222-YC1671) (CAT#: V3S-1222-YC1671)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

Inquiry

Recombinant Anti-LAG3 Antibody (V3S-1222-YC1672) (CAT#: V3S-1222-YC1672)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

Inquiry

Recombinant Anti-LAG3 Antibody (V3S-1222-YC1673) (CAT#: V3S-1222-YC1673)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

Inquiry

Recombinant Anti-LAG3 Antibody (V3S-1222-YC1674) (CAT#: V3S-1222-YC1674)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

Inquiry

Recombinant Anti-LAG3 Antibody (V3S-1222-YC1675) (CAT#: V3S-1222-YC1675)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

Inquiry

Recombinant Anti-LAG3 Antibody (V3S-1222-YC1676) (CAT#: V3S-1222-YC1676)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

Inquiry

Recombinant Anti-LAG3 Antibody (V3S-1222-YC1677) (CAT#: V3S-1222-YC1677)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

Inquiry

Recombinant Anti-LAG3 Antibody (V3S-1222-YC1678) (CAT#: V3S-1222-YC1678)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

Inquiry

Recombinant Anti-LAG3 Antibody (V3S-1222-YC1679) (CAT#: V3S-1222-YC1679)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

Inquiry

Recombinant Anti-LAG3 Antibody (V3S-1222-YC1680) (CAT#: V3S-1222-YC1680)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

Inquiry

Recombinant Anti-LAG3 Antibody (V3S-1222-YC1681) (CAT#: V3S-1222-YC1681)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

Inquiry

Recombinant Anti-LAG3 Antibody (V3S-1222-YC1682) (CAT#: V3S-1222-YC1682)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

Inquiry

Recombinant Anti-LAG3 Antibody (V3S-1222-YC1683) (CAT#: V3S-1222-YC1683)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

Inquiry

Recombinant Anti-LAG3 Antibody (V3S-1222-YC1684) (CAT#: V3S-1222-YC1684)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

Inquiry

Recombinant Anti-LAG3 Antibody (V3S-1222-YC1685) (CAT#: V3S-1222-YC1685)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

Inquiry

Recombinant Anti-LAG3 Antibody (V3S-1222-YC1686) (CAT#: V3S-1222-YC1686)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

Inquiry

Recombinant Anti-LAG3 Antibody (V3S-1222-YC1687) (CAT#: V3S-1222-YC1687)

Target: LAG3

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

For research use only, not directly for clinical use.


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