Lymphotoxin alpha (LTA) is also known as TNFSF1 or tumor necrosis factor-beta (TNFB). Produced by lymphocytes, LTA is a cytokine member belonging to the tumor necrosis factor family. The LTA homotrimer protein is secreted while the LTA heterotrimer protein is membrane-bounded. LTA is associated with autoimmune diseases such as psoriatic arthritis and leprosy.
Its Gene ID: 4049, UniProtKB ID: P01374, and OMIM ID: 153440.
LTA has a high cancer therapeutic potential with the pro-tumor mechanisms of LTA in malignant Hodgkin tumor cells. LTA has the following functions:
Fig.1 Immunoregulatory effect of LTA-mediated receptor cross-talking on DCs. 1
Anti-tumor strategies based on the blockade of the LTA axis have been developed for the treatment of LTA pathological diseases and all kinds of cancers such as lymphoma. The strategies disrupting the interaction of LTA signaling may be explored.
Creative Biolabs offers anti-LTA antibodies for immunoassays, including immunohistochemistry, flow cytometry, blocking, and Neutralization. These antibodies with good purity and specificity were performed quality control with commercial human TNF beta antigens.
Fig.2 Recombinant human TNF beta protein was detected in ELISA using anti-LTA antibody (V3S-0622-YC2110).
Fig.3 Recombinant human TNF beta protein was probed with anti-LTA antibody (V3S-0622-YC2110) in Western blot.
Fig.4 Recombinant human TNF beta protein was detected with anti-LTA antibody (V3S-0622-YC2110) in Dot blot.
Anti-LTA Neutralizing Antibody (V3S-0622-YC2110) (CAT#: V3S-0622-YC2110)
Target: LTA
Host Species: Human
Target Species: Human,
Application: WB,DB,Neut,ELISA,IF,IP,FuncS,FC,ICC,
Recombinant Anti-LTA Antibody (V3S-0622-YC3645) (CAT#: V3S-0622-YC3645)
Target: LTA
Host Species: Human
Target Species: Staphylococcus aureus,
Application: ELISA,
Recombinant Anti-LTA Antibody (V3S-0622-YC3646) (CAT#: V3S-0622-YC3646)
Target: LTA
Host Species: Human
Target Species: Gram-positive bacteria (GPB),
Application: ELISA,
Anti-LTA Neutralizing Antibody (V3S-0522-YC1580) (CAT#: V3S-0522-YC1580)
Target: LTA
Host Species: Human
Target Species: Human,
Application: ELISA,FC,Block,
Anti-LTA Neutralizing Antibody (V3S-0522-YC1581) (CAT#: V3S-0522-YC1581)
Target: LTA
Host Species: Human
Target Species: Human,
Application: ELISA,FC,Block,
Anti-LTA Neutralizing Antibody (V3S-0522-YC1582) (CAT#: V3S-0522-YC1582)
Target: LTA
Host Species: Human
Target Species: Human,
Application: ELISA,FC,Block,
Anti-LTA Neutralizing Antibody (V3S-0522-YC1583) (CAT#: V3S-0522-YC1583)
Target: LTA
Host Species: Human
Target Species: Human,
Application: ELISA,FC,Block,
Anti-LTA Neutralizing Antibody (V3S-0822-YC2067) (CAT#: V3S-0822-YC2067)
Target: LTA
Host Species: Mouse
Target Species: Human,
Application: ELISA,ELISpot,Neut,
Anti-LTA Neutralizing Antibody (V3S-0822-YC2068) (CAT#: V3S-0822-YC2068)
Target: LTA
Host Species: Human
Target Species: Human,
Application: Neut,ELISA,FC,
Anti-LTA Neutralizing Antibody (V3S-0822-YC2069) (CAT#: V3S-0822-YC2069)
Target: LTA
Host Species: Mouse
Target Species: Human,
Application: ICC,Neut,
Recombinant Anti-LTA Antibody (V3S-1022-YC1961) (CAT#: V3S-1022-YC1961)
Target: LTA
Host Species: Mouse
Target Species: Human,
Application: ELISA,
Recombinant Anti-LTA Antibody (V3S-1022-YC1962) (CAT#: V3S-1022-YC1962)
Target: LTA
Host Species: Mouse
Target Species: Human, Cynomolgus,
Application: ELISA,
Recombinant Anti-LTA Antibody (V3S-1022-YC1963) (CAT#: V3S-1022-YC1963)
Target: LTA
Host Species: Mouse
Target Species: Human,
Application: ELISA,
Recombinant Anti-LTA Antibody (V3S-1022-YC1964) (CAT#: V3S-1022-YC1964)
Target: LTA
Host Species: Mouse
Target Species: Human, Cynomolgus,
Application: ELISA,
Recombinant Anti-LTA Antibody (V3S-1222-YC16) (CAT#: V3S-1222-YC16)
Target: LTA
Host Species: Human
Target Species: Human,
Application: WB,