MCF-7 breast cancer cell line
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The MCF-7 cell line, which was established from a pleural effusion at the Michigan Cancer Foundation in 1973, is by far the most commonly used xenograft model of breast cancer. Despite its origin from the metastases of an advanced tumor, the cell line is noninvasive and represents a model of early-stage disease due to the presence of functional ER and estrogen dependence for growth both in vitro and in vivo.