MDMA Specific Neutra™ Antibody Products

Accelerate Your Research and Development!

Creative Biolabs’ MDMA Specific Antibody Products are engineered to provide unparalleled precision and reliability for your research and diagnostic needs. These antibodies offer specific solutions for detecting MDMA and its related compounds, enabling researchers to accurately quantify drug presence, study pharmacokinetic profiles, and develop robust diagnostic tools. Our solutions facilitate the development of sensitive immunoassays, support forensic analysis, and aid in understanding the biological impact of MDMA, providing a crucial tool for both basic science and applied research.

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Introduction of MDMA

3,4-Methylenedioxymethamphetamine (MDMA) is a synthetic compound primarily known for its empathogenic and entactogenic properties, alongside stimulant and mild psychedelic effects. As an amphetamine derivative, its molecular structure incorporates a methylenedioxy group bound to the amphetamine backbone. In biological systems, MDMA exerts its effects primarily by increasing the extracellular concentrations of monoamine neurotransmitters—serotonin (5-HT), dopamine (DA), and norepinephrine (NE)—in the brain. It achieves this by acting as a substrate for and reversing the action of their respective transporters (serotonin transporter (SERT), dopamine transporter (DAT), and norepinephrine transporter (NET)).

Fig. 1 Ball-and-stick model of the MDMA molecule. Distributed under CC BY-SA 4.0, from Wiki, without modification

The therapeutic potential of MDMA, particularly in MDMA-assisted psychotherapy for Post-Traumatic Stress Disorder (PTSD), is attributed to its ability to foster empathy, reduce fear responses (by modulating amygdala activity), and enhance emotional openness, creating a conducive environment for therapeutic processing. However, it is crucial to acknowledge the potential for neurotoxicity associated with MDMA, especially with recreational abuse. Research indicates that high doses or chronic exposure can lead to neurotoxic effects on dopaminergic and serotonergic neurons. Mechanisms proposed include excitotoxicity mediated by reactive oxygen species (ROS) and nitric oxide (NO) leading to reactive nitrogen species (RNS), altered monoamine metabolism, glutamate excitotoxicity, agonism of 5-HT2A receptors, and the formation of neurotoxic metabolites. The involvement of apoptotic proteins (e.g., caspases, Bcl-2 family genes, p53) and inflammatory cytokines (e.g., IL-6, TNF-α, COX-2) in MDMA-induced neurotoxicity has also been identified in various research models, particularly in rodents. Understanding these complex molecular interactions is vital for both therapeutic development and risk mitigation.

Fig. 2 MDMA's impacts on serotonin (5HT) and norepinephrine (NE) systems.¹

Antibodies Against MDMA

Antibodies designed to specifically target MDMA and its metabolites offer powerful tools for research, diagnostics, and potentially even therapeutic interventions in cases of overdose. These antibodies are developed to bind with high affinity and specificity to the MDMA molecule, allowing for its precise detection and quantification in various matrices.

For instance, published data highlights the successful engineering of single-chain variable fragment (scFv) antibodies that exhibit high affinity not only for methamphetamine (METH) but also for (+)MDMA. Such antibodies, like the scFv6H4, demonstrate similar ligand affinities and stereospecificity, binding preferentially to the (+) isomers. This high affinity and specificity enable these antibodies to effectively sequester MDMA, potentially altering its pharmacokinetic profile in vivo by redistributing the drug into the serum, which could be leveraged for rapid detoxification strategies in overdose scenarios. Creative Biolabs’ MDMA Specific Antibody Products build upon this scientific foundation, offering highly characterized antibodies suitable for a range of applications requiring precise MDMA recognition.

Why Choose Us?

Creative Biolabs stands out as a leader in antibody development, driven by our unwavering commitment to scientific excellence and a deep understanding of complex biochemical targets. Our MDMA Specific Antibody Products are designed to provide you with superior tools for your research and diagnostic needs.

Key benefits of collaborating with Creative Biolabs:

• Unwavering Scientific Excellence: Our foundation is built on over two decades of specialized expertise in biological sciences, ensuring cutting-edge technology and rigorous scientific approaches.
• Superior Specificity and Sensitivity: Our MDMA Specific Antibody Products offer unparalleled specificity and sensitivity, which are crucial for obtaining accurate and reliable results in forensic, clinical, and research settings.
• Advanced Protein Engineering: We leverage state-of-the-art protein engineering techniques to design and optimize antibodies for optimal performance.
• Stringent Quality Control: Every antibody undergoes rigorous quality control processes, ensuring the highest standards of purity, consistency, and functionality.
• Accurate and Reliable Results: Our commitment to quality translates directly into highly accurate and reliable data for your projects, minimizing variability and maximizing confidence in your findings.

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REFERENCES

1. Drevin, Guillaume et al. “Pharmacogenomics of 3,4-Methylenedioxymethamphetamine (MDMA): A Narrative Review of the Literature.” Pharmaceutics vol. 16,8 1091. 20 Aug. 2024, DOI:10.3390/pharmaceutics16081091. Distributed under Open Access license CC BY 4.0, without modification.