NCAM1 Specific Neutra™ Antibody Products

Neural Cell Adhesion Molecule 1 (NCAM1), also known as NCAM or CD56, is a critical member of the immunoglobulin superfamily. NCAM1 is a glycoprotein mainly found on the surface of neurons, glial cells, and skeletal muscle. NCAM1 is also detected in T cells and dendritic cells. NCAM1 has been reported to be a critical regulator of cell-cell adhesion, synaptic plasticity, and neurite growth.

Its Gene ID: 4684, UniProtKB ID: P13591, and OMIM ID: 116930.

Functions

NCAM1 is a crucial regulator of cell-cell interactions and cell-matrix interactions during development and differentiation. NCAM1 participates in the development of the nervous system by regulating neurogenesis and neurite outgrowth. Furthermore, NCAM1 plays a crucial role in a variety of brain-related biological processes, including neuronal migration, axon branching, and synaptogenesis. In nerves, NCAM1 regulates homogeneous interactions between neurons and muscles. It is worth noting that NCAM1 is also a key regulator of the expansion of T cells and dendritic cells, which are closely associated with immune surveillance.

NCAM1 Signaling

NCAM1 is reported to signal through interactions with N-cadherin, fibroblast growth factor receptor (FGFR), and other components of the extracellular matrix, triggering signaling cascades involving MAPK, FAK, and PI3K. NCAM1 also acts as a signal transduction receptor molecule and is involved in regulating various biological phenomena, including cell adhesion, proliferation, and survival.

Fig.1 NCAM1 signaling.¹

Therapeutics Targeting NCAM1

In anatomic pathology, NCAM1 may serve as a specific marker to identify certain tumors. In addition, NCAM1 has been closely linked to rabies. In recent years, NCAM1 has emerged as a target molecule for experimental antibody immunotherapy. For example, radioimmunoconjugates targeting NCAM1 showed promising signs of clinical response.

NCAM1 Antibody

A wide range of highly specific antibodies targeting NCAM1 are available at Creative Biolabs. Our antibodies are expressed with a specific mammalian cell transient expression system and purified by affinity chromatography. In addition, affinity testing and binding validation provide further assurance that the final product meets your requirements. In addition to diverse formats, such as monoclonal antibodies and neutralizing antibodies, a variety of conjugations can also be achieved, such as biotin, PE as well as immunofluorescence.

As a leader in the field of NCAM1 antibody research, Creative Biolabs will be your faithful partner. We always adhere to the principle of quality first and provide high-quality NCAM1-targeting antibody products to customers in more than 50 countries and regions around the world. Please do not hesitate to contact us if you are interested in our NCAM1 antibody products.

REFERENCE

1. Rocha, Renato, and Rui Henrique. "Insulinoma-Associated Protein 1 (INSM1): Diagnostic, Prognostic, and Therapeutic Use in Small Cell Lung Cancer." Journal of Molecular Pathology 3.3 (2022): 140-167. Distributed under Open Access license CC BY 4.0, without modification.