Sialyl Tn

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Sialyl-Tn (STn) is a carbohydrate antigen discovered as a cancer marker in the early 80s. Sialyl-Tn antigen (STn) is a short O-glycan containing a sialic acid residue α2,6-linked to GalNAcα-O-Ser/Thr. The biosynthesis of STn is mediated by a specific sialyltransferase termed ST6GalNAc I, which competes with O-glycans elongating glycosyltransferases and prevents cancer cells from exhibiting longer O-glycans. While weakly expressed by fetal and normal adult tissues, STn is expressed by more than 80% of human carcinomas and in all cases, STn detection is associated with adverse outcome and decreased overall survival for the patients.
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Recombinant Anti-Sialyl Tn Antibody (V3S-1222-YC7) (CAT#: V3S-1222-YC7)

Target: Sialyl Tn

Host Species: Mouse

Application: ELISA,IHC,

For research use only, not directly for clinical use.


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