Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. They mediate protein-carbohydrate interactions by selectively binding to differentsialic acid moieties present on glycolipids and glycoproteins. The two proteins are members of the SIGLEC3-like subfamily of SIGLECs.