Sulfonamides Specific Neutra™ Antibody Products

Are you struggling with accurate detection of sulfonamides in complex matrices, managing antibiotic resistance, or ensuring compliance with stringent residue limits? Creative Biolabs' sulfonamides specific Neutra™ antibody products leverage advanced phage display and affinity maturation technologies to deliver ultra-specific, high-affinity antibodies, enabling rapid quantification, targeted therapeutic development, and robust regulatory adherence.

Introduction to Sulfonamides

Sulfonamides (SAs), synthetic antimicrobial agents characterized by a para-aminobenzenesulfonamide core, have been widely utilized since the 1930s for their broad-spectrum activity against Gram-positive and Gram-negative bacteria. These compounds competitively inhibit dihydropteroate synthase (DHPS), a critical enzyme in bacterial folate synthesis, thereby disrupting nucleic acid and protein synthesis.

• Structure

The SA scaffold consists of a sulfonamide group (-SO₂NH₂) linked to a benzene ring with an amino group at the para position. Structural diversity arises from substitutions at the N¹ position (e.g., sulfadiazine, sulfamethoxazole), which modulate pharmacokinetics and antimicrobial potency. The conserved sulfonamide moiety is essential for target binding, while variable groups influence solubility, half-life, and cross-reactivity.

• Related Mechanisms

SAs directly impede the bacterial folate pathway by mimicking para-aminobenzoic acid (PABA), a DHPS substrate. In eukaryotic systems, prolonged SA exposure may interfere with host metabolic processes, such as thyroid hormone synthesis and cytochrome P450 activity, contributing to adverse effects like hypersensitivity or endocrine disruption.

Fig.1 Mechanisms of action of antimicrobial sulfonamides.¹

• Associated Pathologies

While SAs are pivotal in treating infections and preventing livestock diseases, their overuse in veterinary and agricultural settings has led to concerning residues in animal-derived foods (e.g., meat, dairy). Chronic low-dose exposure in humans is linked to allergic reactions, antimicrobial resistance, and potential carcinogenicity. Regulatory agencies enforce maximum residue limits (MRLs; e.g., 100 µg/kg total SAs in meat) to mitigate public health risks.

Applications of Anti-Sulfonamides Neutralizing Antibodies

• Residue Detection in Food Safety

Anti-SAs antibodies enable rapid, high-throughput screening of animal-derived products, addressing challenges in false positives from cross-reactive compounds. Their integration into portable assays supports on-site testing for regulatory inspections.

• Antimicrobial Resistance Research

By profiling SA-resistant bacterial strains, these antibodies aid in identifying resistance biomarkers and evaluating novel DHPS inhibitors, accelerating the development of next-generation antimicrobials.

• Clinical Diagnostics

In therapeutic settings, antibody-based assays guide personalized treatment regimens, reducing adverse drug reactions and improving patient outcomes in SA-treated infections.

• Environmental Monitoring

Antibodies facilitate sensitive detection of SAs in agricultural runoff, supporting sustainable practices and mitigating ecotoxicological risks.

Our Anti-Sulfonamides Antibody Products

Creative Biolabs' anti-sulfonamides antibodies are engineered for unparalleled specificity to discriminate between structurally similar SAs and their metabolites. Applications include:

- Residue Monitoring: Detect trace SA residues in food products via ELISA or lateral flow assays, ensuring compliance with global MRL standards.

- Therapeutic Drug Monitoring: Quantify SA levels in clinical samples to optimize dosing and minimize toxicity.

- Mechanistic Studies: Investigate SA resistance mechanisms by analyzing DHPS mutations or efflux pump activity in bacterial isolates.

- Environmental Surveillance: Track SA contamination in water or soil to assess ecosystem impact.

Creative Biolabs provides sulfonamides specific Neutra™ antibody products that empower researchers and regulators to address antimicrobial resistance, food safety breaches, and environmental contamination with unmatched precision. Engineered for sensitivity, specificity, and scalability, our antibodies are vital tools for advancing One Health initiatives.

Contact our team today to discuss custom solutions for your SA-related challenges.

REFERENCE

1. Giles, Amber, et al. "Sulfonamide allergies." Pharmacy 7.3 (2019): 132. Distributed under Open Access license CC BY 4.0, without modification. https://doi.org/10.3390/pharmacy7030132