Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. Diseases associated with TDRD3 include Fragile X Syndrome and Atrophic Muscular Disease. Among its related pathways are Chromatin Regulation / Acetylation and Translational Control. Gene Ontology (GO) annotations related to this gene include chromatin binding.