WNV VLP Specific Neutra™ Antibody Products

WNV VLP Specific Neutra™ Antibody Products, Accelerate Your Research with Creative Biolabs! Are you facing challenges in developing effective tools for West Nile Virus research? Our WNV VLP Specific Neutra™ Antibody Products help you obtain reliable and specific reagents through our innovative antibody development and characterization.

Overview of WNV VLP

West Nile Virus virus-like particles (VLPs) serve as harmless duplicates of the authentic WNV. Viral structural proteins contain Envelope (E) and premembrane (prM) proteins, and they serve as the primary building blocks for the self-assembling structures. Mosquito-borne WNV belongs to the Flavivirus genus. WNV consists of single-stranded RNA. West Nile fever represents a serious health condition resulting from this virus, which may lead to neurological complications.

Structure

The structure of WNV VLPs matches that of infectious WNV virions despite not containing viral RNA. Due to their structural similarity, they serve as superior research tools for analyzing viral entry mechanisms and immune system responses along with vaccine and diagnostic development. Receptor binding and membrane fusion during viral infection depend heavily on the E protein that appears on the VLP surface.

Related Signaling Pathways

VLPs lack the ability to start viral replication, but they can attach to cellular receptors and activate signaling pathways. The E protein on the surface of cells will bind to specific receptors on the cell surface after cell interaction. The interaction between E protein and cellular receptors sets off multiple signaling cascades inside the cell. Grasping how these cellular processes operate provides key information about viral infection initiation and host defense response, which aids in creating effective countermeasures.

Fig. 1 Innate immune response signaling within host cells during WNV infection.¹

Relevent Diseases

WNV infection can cause a range of symptoms in humans, from mild flu-like illness to severe neurological diseases such as encephalitis and meningitis.

Utilization of Anti-WNV VLP Antibody

Anti-WNV VLP antibodies have significant applications in both research and clinical settings. Here are two key examples:

• Widely Used in Diagnostic Assays

Anti-WNV VLP antibodies function as indispensable components for diagnostic tests aimed at identifying WNV infections. Through ELISAs and similar immunoassays, antibodies capture WNV antigens from patient samples to allow precise and quick diagnostic results. The capacity to monitor viral spread and identify infected people through these assays supports public health measures to contain outbreaks.

• Research and Vaccine Development

The research into WNV infection mechanisms and vaccine development depends heavily on anti-WNV VLP antibodies as essential tools. Antibodies against WNV VLPs help researchers investigate viral neutralization processes and locate essential epitopes on VLP surfaces to evaluate vaccine candidate immunogenicity. These antibodies serve as tools to evaluate vaccine performance by measuring the production of neutralizing antibodies, which represent the main measure of vaccine effectiveness.

Creative Biolabs equips researchers with cutting-edge tools to combat WNV VLP and propel scientific progress. Our comprehensive antibody portfolio offers a wide array of targeting possibilities for key viral proteins. These antibodies perform efficiently in various applications, including ELISA, etc.

REFERENCE

1. Quicke, Kendra M., and Mehul S. Suthar. "The innate immune playbook for restricting West Nile virus infection." Viruses 5.11 (2013): 2643-2658. Distributed under Open Access license CC BY 4.0, without modification. https://doi.org/10.3390/v5112643