X-linked inhibitor of apoptosis

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XIAP is a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Pseudogenes of this gene are found on chromosomes 2 and 11.
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Anti-XIAP Neutralizing Antibody (V3S-0822-YC2646) (CAT#: V3S-0822-YC2646)

Target: XIAP

Host Species: Mouse

Target Species: Human,

Application: ELISA,IHC,Neut,

For research use only, not directly for clinical use.


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