ZNRF3 Specific Neutra™ Antibody Products

Zinc and Ring Finger 3 (ZNRF3), a member of the E3 ubiquitin ligase family, acts as a negative regulator of Wnt signaling. Its structural organization, featuring an intracellular RING domain, a transmembrane domain, an extracellular domain, and a signal peptide, enables it to modulate Wnt signaling uniquely. Recognized as a critical contributor to tumorigenesis and development, ZNRF3 plays a substantial role in suppressing Wnt signaling pathways. This pathway is indispensable for many cellular functions, encompassing cell proliferation, differentiation, migration, and programmed cell death (apoptosis). Controlling Wnt receptors' degradation ensures proper signal transduction necessary for development and tissue maintenance. Its dysfunction can lead to significant pathological conditions, making it an important research focus in developmental biology and oncology.

Its Gene ID: 84133, UniProtKB ID: Q9ULT6, and OMIM ID: 612062.

ZNRF3-Wnt Pathway

Belonging to the Goliath family of transmembrane RING domain E3 ligases, both ZNRF3 and its functional counterpart, Ring Finger Protein 43 (RNF43), act as inhibitors within the Wnt signaling pathway. They suppress Wnt signaling by facilitating the ubiquitination, internalization, and degradation of the Wnt receptors FZD and LRP6, as depicted in Fig.1. Conversely, R-spondins (RSPO) are secreted proteins renowned for their ability to amplify Wnt signaling. By binding to ZNRF3 and its counterpart RNF43, they hinder the ubiquitin ligase activity of these proteins. This interruption leads to the stabilization and accumulation of Wnt receptors on the cell surface, thereby augmenting Wnt signaling. Overall, The ZNRF3/RNF43 signaling module regulates Wnt receptor turnover, a key mechanism in Wnt signaling. It forms a robust negative feedback loop in the Wnt pathway.

Fig.1 The ZNRF3/RNF43 signaling in Wnt.¹

ZNRF3 Specific Antibodies in Cancer

ZNRF3 is a negative regulator of the Wnt signaling pathway, promoting the degradation of Wnt receptors. The disruption of Wnt signaling has been linked to several malignancies, such as hepatocellular carcinoma, colorectal cancer, and pancreatic cancer. Loss-of-function mutations in ZNRF3 can enhance Wnt signaling, leading to uncontrolled cell proliferation and tumor growth. ZNRF3 antibodies are invaluable for studying this key regulator of the Wnt signaling pathway, offering crucial insights into ZNRF3's role in tumor biology.

Services

Creative Biolabs provides a diverse range of anti-ZNRF3 antibody products, each recombinantly expressed to ensure high specificity and efficacy. These antibodies are suitable for various applications. If you would like further details or wish to discuss your particular needs, please don't hesitate to get in touch with us. We are dedicated to assisting your research and development endeavors with top-notch products and outstanding customer service.

REFERENCE

1. Hao, Huai-Xiang, Xiaomo Jiang, and Feng Cong. "Control of Wnt receptor turnover by R-spondin-ZNRF3/RNF43 signaling module and its dysregulation in cancer." Cancers8.6 (2016): 54. Under open access license CC BY 4.0, without modification.