Description | The antibody against amyloid plaques was derived by immunizing with a 16 amino acid peptide of beta-amnyloid (acids 1-16) conjugated to KLH. The antibody has specific activity to Aβ in preventing its toxic affects on PC12 cells. |
Clonality | Monoclonal |
Host Species | Mouse |
Target Species | Human |
Immunogen | A 16 amino acid peptide of beta-amyloid (acids Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys) conjugated to KLH. |
Epitope | The epitope is located in amino acids Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys. |
Affinity | The KD value, 0.1 uM, were determined using 2:1 kinetics of binding of analyte (BSA-cSNK). |
Isotype | IgM |
Expression Species | HEK293F or CHO |
Conjugation | None |
Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
Endotoxin | <1 EU/mg |
Purification | Protein G affinity purified |
Sterility | 0.2 μM filtered |
Formulation | PBS, pH 7.4 |
Preservation | No preservatives |
Stabilizer | No stabilizers |
Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
Application | ELISA |
Application Notes | The antibody is recommended for detection of APP by ELISA assay. |
ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
WB | Western Blot Protocol |
FC | Flow Cytometry Protocol |
Target | APP |
Alternative Name | Amyloid Beta Precursor Protein; Amyloid Beta (A4) Precursor Protein; Alzheimer Disease Amyloid Protein; Cerebral Vascular Amyloid Peptide; Amyloid Precursor Protein; Peptidase Nexin-II; Protease Nexin-II; PreA4; PN-II; ABPP; APPI; CVAP; AD1; Beta-Amyloid Precursor Protein; 508F(Fv) |
Gene ID | 351 |
UniProt | P05067 |
Research Area | Neuroscience |