This product is a human monoclonal antibody that binds human Colony Stimulating Factor-1 Receptor (CSF-1R). Antibody 1 binds to the human but not mouse CSF-IR and inhibits CSF-1 binding to human CSF-1 R. The antibody was found to internalize and induce CSF-1R degradation. It also can be used to stimulate ADCC in cell such as monocytes, macrophages and tumors.
Antibody 1 primarily binds to the second Ig domain of CSF-1R.
HEK293F or CHO
>95%, determined by SDS-PAGE and SEC-HPLC
Protein A affinity purified
0.2 μM filtered
PBS, pH 7.4
Store at 4°C within a week. For longer storage, aliquot and store at -20°C.
ELISA; Block; ADCC; FuncS
The antibody is recommended for detection of CSF1R by ELISA, Block, ADCC, FuncS assays.