The mAb 3949 is an antibody which binds with high affinity to PAR2. mAb 3949 exhibited blocking activity against activation of PAR2 both with trypsin and with activating peptide in the functional FLIPR assay. The binding of mAb 3949 to ECL2 provides a structural rationale for the antagonist activity of mAb 3949 IgG.
HEK293F or CHO cell line
Protein G purified
0.2 μM filtered
PBS, pH 7.4
Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics.