| Description | The antibody protected mice from encephalitis and death following ocular inoculation with the virus. The mAb (anti-gB) protects against encephalitis even when immunization is delayed until 48 hours post-infection. It significantly reduced the severity of epithelial keratitis and reduced the frequency of persistent viral infection in an inbred mouse model. Murine antibody has been shown to neutralize HSV-1 in vitro without the need for complement. Both humanized and murine versions resulted in a 90% reduction in plaque at an antibody concentration of 7 nM (1 ug/mL). |
| Clonality | Monoclonal |
| Host Species | Mouse |
| Target Species | Herpes Simplex Virus (HSV) |
| Isotype | IgG |
| Expression Species | HEK293F or CHO cell line |
| Conjugation | Unconjugated |
| Purity | >95% |
| Endotoxin | <1 EU/mg |
| Form | Liquid |
| Purification | Protein G purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics. |
| Application | ELISA; WB; Neut |
| Application Notes | The antibody resulted in a 90% reduction in plaque at an antibody concentration of 7 nM (1 ug/mL). |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | HSV gB |
| Alternative Name | Herpesvirus glycoprotein B; HSV gB |
| Research Area | Microbiology |
