The Fd79 antibody protected mice from encephalitis and death following ocular inoculation with the virus. Fd79 (anti-gB) protects against encephalitis even when immunization is delayed until 48 hours post-infection. It significantly reduced the severity of epithelial keratitis and reduced the frequency of persistent viral infection in an inbred mouse model. Murine Fd79 has been shown to neutralize HSV-1 in vitro without the need for complement. Both humanized and murine Fd79 resulted in a 90% reduction in plaque at an antibody concentration of 7 nM (1 ug/ml).
Herpes Simplex Virus (HSV)
HEK293F or CHO cell line
Protein G purified
0.2 μM filtered
PBS, pH 7.4
Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics.
ELISA; WB; Neut
The antibody Fd79 resulted in a 90% reduction in plaque at an antibody concentration of 7 nM (1 ug/ml).