| Description | This is a monoclonal antibody, namely the humanized anti-myostatin full-length antibody 510C2. The IC₅₀ values of monoclonal antibodies 510C2 were determined to be 5.15 nM under the tested conditions with GDF-8. Notably, when tested with GDF-11, 510C2 did not exhibit any cross-neutralization activity in this assay. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Human |
| Epitope | aa 43-57 |
| IC50 | 5.15 nM |
| Affinity | KD = 80 pM |
| Isotype | Human IgG |
| Expression Species | HEK293F or CHO |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein A affinity purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | ELISA; Neut |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | MSTN |
| Alternative Name | Myostatin; GDF8; Growth Differentiation Factor 8; Growth/Differentiation Factor 8; MSLHP; GDF-8 |
| Gene ID | 2660 |
| UniProt | O14793 |
| Related pathway | MSTN signaling pathway |
| Research Area | Rare Disease; Signal Pathway |
| Related Disease | Renal disease, Cardiac failure or disease, and Liver disease |
