| Description |
This product maintains neutralizing activity against Omicron and inhibits ACE2 binding. |
| Clonality |
Monoclonal |
| Host Species |
Human |
| Target Species |
SARS-CoV-2 Omicron variant |
| Cross Reactivity |
WT, Alpha, Beta, and Gamma, but not Delta |
| Immunogen |
SARS-CoV-2 Spike RBD protein |
| Neutralization Potency |
The antibody inhibit the binding of ACE2 to the Omicron spike trimer with a median inhibitory con-centration of 1.8 nM. |
| Affinity |
The Fab format bound the Omicron spike trimer. (KD = 3.2 ± 3.0 nM)
The Fab format bound the WT spike trimer. (KD = 12.2 ± 11.6 nM)
The IgG format bound the Omicron spike trimer. (KD = 0.4 ± 0.1 nM)
The IgG format bound the WT spike trimer. (KD = 0.5 ± 0.3 nM) |
| Isotype |
Human IgG |
