APP Specific Recomb™ Antibody (V3S-0324-FY8), Mouse IgG (CAT#: V3S-0324-FY8)

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Datasheet

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Summary
Property
Applications
Protocols
Target

Summary

Description APP Antibody (V3S-0324-FY8), IBL-102, is an antibody designed to selectively and robustly bind to Aβ oligomers. The IBL-102 antibody demonstrates a high degree of specificity, exclusively targeting Aβ42 molecules with a turn structure at positions 22 and 23. APP (aa 1-7)Antibody (V3S-0324-FY9) is a mouse monoclonal antibody that is developed to target Abeta 1-40. Specifically, it is an N-terminus (Aβ 1-7) Aβ-specific monoclonal antibody. Its applications include use in ELISA, FC, and WB assays. APP (aa 13-21) Antibody (V3S-0324-FY10), known as ACI-01-Ab7C2 or mC2, is a mouse IgG2b antibody. It demonstrates a 36.0% higher affinity for the peptide containing its specific epitope (amino acids 13-21 of the Aβ1-42 sequence) compared to the entire Aβ1-42 protein. APP (aa 22-35) Antibody (V3S-0324-FY11) is a mouse IgG2a monoclonal antibody. The clone 6G binds to the C-terminus of various truncated Aβ peptide, for example, 22-35, 1-38, 1-40, 1-42, and 1-43. APP (aa 1-16) Antibody (V3S-0324-FY12), Mab 2324, is a mouse IgG2b type. The clone was generated through the immunization of a mouse with the Aβ 1-40 peptide. The Mab 2324 targets a N-terminal epitope of Aβ and specifically binds to Aβ without cross-reacting with β-APP. APP (aa 33-42) Antibody (V3S-0324-FY13) is a mouse IgG1 monoclonal antibody known as 21F12, which exhibits a strong affinity for the dense core of plaques in AD sections. The antibody specifically targets the epitope within residues Aβ 33-42.
Clonality Monoclonal
Host Species Mouse
Target Species Human
Immunogen G9C, E22P-Aβ9-35 peptide.
Epitope Targets a turn structure at amino acid positions 22 and 23 of Aβ42.
Affinity >100 nM for Aβ42, 3.1 nM for E22P-Aβ42, 1.7 nM for E22P-Aβ42 dimer
Isotype Mouse IgG

Property

Expression Species HEK293F or CHO
Conjugation None
Purity >95%, determined by SDS-PAGE and SEC-HPLC
Endotoxin <1 EU/mg
Purification Protein G affinity purified
Sterility 0.2 μM filtered
Formulation PBS, pH 7.4
Preservation No preservatives
Stabilizer No stabilizers
Storage Store at 4°C within a week. For longer storage, aliquot and store at -20°C.

Applications

Application ELISA; IHC; Cyt
Application Notes ELISA: 0.125-1 µg/mL
IHC: 5-20 µg/mL
Cytotoxicity: 0.1 mg/mL

Protocols

ELISA Enzyme-Linked Immunosorbent Assay Protocol
WB Western Blot Protocol
FC Flow Cytometry Protocol

Target

Target APP
Alternative Name Amyloid Beta Precursor Protein; Amyloid Beta (A4) Precursor Protein; Alzheimer Disease Amyloid Protein; Cerebral Vascular Amyloid Peptide; Amyloid Precursor Protein; Peptidase Nexin-II; Protease Nexin-II; PreA4; PN-II; ABPP; APPI; CVAP; AD1; Beta-Amyloid Precursor Protein
Gene ID 351
UniProt P05067
Related pathway MyD88 dependent cascade initiated on endosome and GPCR downstream signalling
Research Area Signal Pathway
Related Disease Alzheimer's disease
For research use only, not directly for clinical use.
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