| Description | APP antibody (V3S-0324-FY8) is an antibody designed to selectively and robustly bind to Aβ oligomers. The antibody demonstrates a high degree of specificity, exclusively targeting Aβ42 molecules with a turn structure at positions 22 and 23. APP (aa 1-7) antibody (V3S-0324-FY9) is a mouse monoclonal antibody that is developed to target Abeta 1-40. Specifically, it is an N-terminus (Aβ 1-7) Aβ-specific monoclonal antibody. Its applications include use in ELISA, FC, and WB assays. APP (aa 13-21) antibody (V3S-0324-FY10) is a mouse IgG2b antibody. It demonstrates a 36.0% higher affinity for the peptide containing its specific epitope (amino acids 13-21 of the Aβ1-42 sequence) compared to the entire Aβ1-42 protein. APP (aa 22-35) antibody (V3S-0324-FY11) is a mouse IgG2a monoclonal antibody. The clone binds to the C-terminus of various truncated Aβ peptide, for example, 22-35, 1-38, 1-40, 1-42, and 1-43. APP (aa 1-16) antibody (V3S-0324-FY12) is a mouse IgG2b type. The clone was generated through the immunization of a mouse with the Aβ 1-40 peptide. The mAb targets a N-terminal epitope of Aβ and specifically binds to Aβ without cross-reacting with β-APP. APP (aa 33-42) antibody (V3S-0324-FY13) is a mouse IgG1 monoclonal antibody, which exhibits a strong affinity for the dense core of plaques in AD sections. The antibody specifically targets the epitope within residues Aβ 33-42. |
| Clonality | Monoclonal |
| Host Species | Mouse |
| Target Species | Human |
| Immunogen | G9C, E22P-Aβ9-35 peptide. |
| Epitope | Targets a turn structure at amino acid positions 22 and 23 of Aβ42. |
| Affinity | >100 nM for Aβ42, 3.1 nM for E22P-Aβ42, 1.7 nM for E22P-Aβ42 dimer |
| Isotype | Mouse IgG |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein G affinity purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | ELISA; IHC; Cyt |
| Application Notes | ELISA: 0.125-1 µg/mL IHC: 5-20 µg/mL Cytotoxicity: 0.1 mg/mL |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | APP |
| Alternative Name | Amyloid Beta Precursor Protein; Amyloid Beta (A4) Precursor Protein; Alzheimer Disease Amyloid Protein; Cerebral Vascular Amyloid Peptide; Amyloid Precursor Protein; Peptidase Nexin-II; Protease Nexin-II; PreA4; PN-II; ABPP; APPI; CVAP; AD1; Beta-Amyloid Precursor Protein |
| Gene ID | 351 |
| UniProt | P05067 |
| Related pathway | MyD88 dependent cascade initiated on endosome and GPCR downstream signalling |
| Research Area | Signal Pathway |
| Related Disease | Alzheimer's disease |
