| Description | This monoclonal antibody, known as ACI-01-Ab7C2 or mC2, is a mouse IgG2b antibody. It demonstrates a 36.0% higher affinity for the peptide containing its specific epitope (amino acids 13-21 of the Aβ1-42 sequence) compared to the entire Aβ1-42 protein. |
| Clonality | Monoclonal |
| Host Species | Mouse |
| Target Species | Human |
| Epitope | Amino acids 13-21 |
| Affinity | KD = 41 nM |
| Isotype | Mouse IgG2b |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein G affinity purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | ELISA; IHC |
| Application Notes | Affinity: 0.05-1.0 μM |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | APP |
| Alternative Name | Amyloid Beta Precursor Protein; Amyloid Beta (A4) Precursor Protein; Alzheimer Disease Amyloid Protein; Cerebral Vascular Amyloid Peptide; Amyloid Precursor Protein; Peptidase Nexin-II; Protease Nexin-II; PreA4; PN-II; ABPP; APPI; CVAP; AD1; Beta-Amyloid Precursor Protein |
| Gene ID | 351 |
| UniProt | P05067 |
| Related pathway | MyD88 dependent cascade initiated on endosome and GPCR downstream signalling |
| Research Area | Signal Pathway |
| Related Disease | Alzheimer's disease |
